ECE2016 Eposter Presentations Obesity (69 abstracts)
Copeptin, a marker of vasopressin, decreases significantly in early state after bariatric surgery
Recep Aktimur 1 , Turkan Mete 2 , Suleyman Cetinkunar 3 , Mehmet Yaman 4 , Osman Beton 5 , Emre Avci 6 , Hasan Erdem 3 & Kadir Yildirim 1
1Department of General Surgery, Ministry of Health, Samsun Training and Research Hospital, Samsun, Turkey; 2Department of Endocrinology and Metabolism, Ministry of Health, Samsun Training and Research Hospital, Samsun, Turkey; 3Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey; 4Department of Cardiology, Ministry of Health, Samsun Training and Research Hospital, Samsun, Turkey; 5Department of Cardiology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey; 6Department of Biology/Biochemistry, Faculty of Science and Arts, Hitit University, Çorum, Turkey.
Introduction: Copeptin, the C-terminal fragment of arginine vasopressin pro-hormone, has been associated with the metabolic syndrome (MetS), diabetes mellitus (DM) development. The aim of our study is to evaluate preoperative and postoperative alterations of copeptin in patients who underwent obesity surgery and evaluate any differences between sleeve gastrectomy (SG) and mini gastric bypass (MGB) in terms of copeptin levels.
Subjects and Methods: Twenty five consecutive patients, who were treated for morbid obesity by SG or MGB, between March and April 2015 were included in this study. Diagnosis of MetS was made according to NCEP ATP-III criteria. Blood samples were obtained from patients preoperatively and one month after operation. ELISA technique was used to measure copeptin level in plasma samples.
Resullts: SG and MGB were applied to 11 and 14 patients, respectively. Mean ages (35±8.3 vs. 34.7±7.7, P=0.908) and body mass indexes of the two groups were similar (44.3±2.3 vs 44.2±3.2, P=0.948). Mean preoperative copeptin levels of patients who had SG (0.715±0.619 ng/ml) and MGB (0.577±0.222 ng/ml) were similar (P=0.003). At postoperative 1st month mean weight loss of the patients was 12.4 kg. Postoperative copeptin levels were statistically significantly decreased in both groups compared with preoperative levels (SG; 0.628±0.610 ng/ml, P=0.03, MGB; 0.474±0.180 ng/ml, P=0.01).
Conclusions: Recent studies have demonstrated the association between copeptin level and DM and MetS. Our study is the first one to show that copeptin significantly decrease during early postoperative period after obesity surgery.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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