ECE2016 Eposter Presentations Obesity (69 abstracts)
Medium-term evolution of ghrelin levels according to three types of bariatric surgeries and its relation with HDL and insulin resistance
Concepción Santiago-Fernández 1 , Sara García-Serrano 2, , Monica Tomé 1 , Sergio Valdés 2, , Luis Ocaña-Wilhelmi 4 , Alberto Rodríguez-Cañete 5 , Francisco J. Tinahones 1, , Eduardo García-Fuentes 2, & Lourdes Garrido-Sánchez 1,
1Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Clínico Virgen de la Victoria, Málaga, Spain; 2Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario, Málaga, Spain; 3CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), Málaga, Spain; 4Unidad de Gestión Clínica de Cirugía General, Digestiva y Trasplantes, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Clínico Virgen de la Victoria, Málaga, Spain; 5Unidad de Gestión Clínica de Cirugía General, Digestiva y Trasplantes, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario, Málaga, Spain; 6CIBER Fisiología de la Obesidad y Nutrición (CIBEROBN), Málaga, Spain.
Introduction: Ghrelin is a gastrointestinal peptide involved in the regulation of body weight and energy balance. However, its behavior after bariatric surgery and its relationship with other biochemical variables is still under discussion. We aim to undertake a simultaneous evaluation of the changes in ghrelin levels after three types of bariatric surgery and its relationship with different variables.
Design: The study included 21 non-obese and 103 morbidly obese subjects before and 6 months after bariatric surgery (Roux-en-Y gastric bypass (RYGB) (n=30), biliopancreatic diversion of Scopinaro (BPD) (n=47) and sleeve gastrectomy (SG) (n=26).
Results: Ghrelin was decreased in morbidly obese subjects (P<0.05). A multiple linear regression model showed that ghrelin was positively associated with HDL-cholesterol before bariatric surgery (P=0.037). RYGB increased ghrelin (P<0.05), BPD did not modify significantly ghrelin and SG decreased ghrelin (P<0.05). The percentage of change in ghrelin levels (Δ-ghrelin) was associated with the type of surgery in a multiple linear regression model (P=0.017). When we performed the same analysis only with those morbidly obese subjects in which gastric fundus is not excluded (RYGB and BPD), Δ-ghrelin was negatively associated with Δ-HOMA-IR in a multiple linear regression model (P=0.001).
Conclusion: In conclusion, HDL-cholesterol could be involved in the regulation of baseline ghrelin levels in morbidly obese subjects. Changes in ghrelin levels after bariatric surgery would be associated to the presence/absence of gastric fundus. Insulin resistance would be associated to the evolution of ghrelin levels after bariatric surgery in those techniques in which fundus is not excluded (RYGP and BPD).
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more