ECE2016 Eposter Presentations Obesity (69 abstracts)
Msr1 and Cxcl16 scavenger receptors in adipose tissue are positively associated with BMI and insulin resistance
Concepción Santiago-Fernández 1 , JM García-Almeida 1, , Carolina Gutierrez-Repiso 3 , Juan Alcaide 1 , Luis Ocaña-Wilhelmi 4 , Monica Tomé 1 , Alejandro Rodríguez-Morata 5 , Francisco J Tinahones 1, , Franz Tatzber 6 , Edith Pursch 7 , Eduardo García-Fuentes 2, & Lourdes Garrido-Sánchez 1,
1Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, Málaga, Spain; 2CIBER Physiopathology of Obesity and Nutrition (CIBERObn), Instituto Salud Carlos III, Málaga, Spain; 3Department of Endocrinology and Nutrition, Biomedical Research Institute of Malaga (IBIMA), Regional University Hospital, Malaga, Málaga, Spain; 4Department of Surgery, Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, Málaga, Spain; 5Department of Angiology and Vascular Surgery, Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, Málaga, Spain; 6Medical University of Graz, Centre of Molecular Medicine, Institute of Pathophysiology & Immunology, Gratz, Austria; 7University of Applied Sciences Technikum Wien, Institute of Biochemistry, Vienna, Austria.
Introduction: Obesity is associated with an increasing risk of diabetes and atherosclerosis. Previous studies in animals show that oxidized low-density lipoprotein (Ox-LDL) can be captured by the adipocyte through different scavenger receptors (SR) and thus contribute to the worsening of insulin resistance (IR). We analyze the association between Ox-LDL levels and different SR present in adipose tissue and their relationship with the presence of obesity and insulin resistance (IR).
Design: We study serum levels of Ox-LDL-oxidized and different SR, as well as the levels of mRNA gene expression of different SR (lectin-like oxLDL-1 (LOX-1), macrophage scavenger receptor 1 (MSR1) and chemokine (C-X-C motif) ligand 16 (CXCL16)) in visceral (VAT) and subcutaneous adipose tissue (SAT) from 23 normal weight and 25 morbidly obese patients (MO) depending on their IR (low and high IR).
Results: Serum Ox-LDL and LOX-1 levels are higher in MO patients with high IR (P<0.05). Serum MSR1 levels are higher in the MO patients (P<0.05). MSR-1 mRNA expression level is higher in MO patients with high IR in VAT and SAT (P<0.05). CXCL16 mRNA expression level is higher in MO patients in VAT and SAT (P<0.05). LOX-1 in VAT is positively associated with body mass index (BMI), waist and hips circumferences and cholesterol, and negatively with the HDL-c and adiponectin. MSR1 and CXCL16 in VAT and SAT are positively associated with BMI, waist and hips circumferences, insulin, glucose, HOMA-IR and triglycerides, and negatively associated with adiponectin and HDL-c.
Conclusions: In this study we demonstrate the positive association between MSR1 and CXCL16 mRNA gene expression levels and BMI and IR.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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