ECE2016 Eposter Presentations Obesity (69 abstracts)
Effect of osteocalcin on fat distrubution in premenopausal obese women
Ozen Dedeoglu 1 , Guzin Yaylali 2 , Tolga Yaylali 3 , Senay Topsakal 2 , Fulya Akin 2 , Duygu Herek 4 & Hande Senol 5
1Pamukkale University, Department of Internal Medicine, Denizli, Turkey; 2Pamukkale University, Department of Endocrinology, Denizli, Turkey; 3Pamukkale University, Department of Cardiology, Denizli, Turkey; 4Pamukkale University, Department of Radiology, Denizli, Turkey; 5Pamukkale University, Department of Biostatistics, Denizli, Turkey.
Introduction: Recent studies suggested that plasma levels of osteocalcin (OC) were negatively associated with both fat mass and plasma glucose. These findings may suggest that endocrine function of the osteoblast-derived osteocalcin on fat mass/glucose homeostasis in mice also might exist in humans. The aim of this study was to determine if osteocalcin has any effect on fat distrubution in different parts of body.
Methods: Eighty-six obese premenapousal women (aged 17–55 years) and 56 women with normal BMI took part in this study. Antropometric measurements including waist circumferences (WC) were done. Serum concentrations of fasting blood glucose, insulin, OC were measuresd. Body fat distrubution was evaluated by ultarsonography. Body fat thickness in four regions were measured. Total fat and fat ratio were also measured by Bioelectrical Impedance Analysis (BIA). Epicardial fat thickness (EFT) was measured by echocardiography.
Results: Visceral (VFT), subcutaneous (SFT) and preperitoneal fat thickness (PFT) were significantly higher in obese subjects (P < 0.01). OC was significantly lower in obese subjects. There wasn’t any correlation between OC and VFT, SFT,PFT or EFT. Leg fat mass measured by BIA was negatively correlated with OC (P=0.005, r=−0.328).
| Obese | Control | P | |
| Visseral fat thickness (mm) | 54.17 | 30.04 | 0.000 |
| Preperitoneal fat thickness (mm) | 20.36 | 6.72 | 0.000 |
| Subcutaneous fat thickness (mm) | 34.38 | 18.59 | 0.000 |
| Epicardial fat thickness (mm) | 5.19 | 3.25 | 0.000 |
| Osteocalcin (ml/min) | 18.26 | 22.53 | 0.000 |
Conclusion: Premenopausal obese women have lower OC levels but this doesn’ t seem to be correlated with body fat distrubution in any part of body.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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