Endocrine Abstracts

Introduction: Sleeve gastrectomy is a highly effective bariatric technique for morbidly obese patients thus nutritional deficiencies resulting need routine screening for proper evaluation.

Aim: Little is still known about the nutritional side-effects for this restrictive bariatric procedure and our study aims to evaluate the impact of sleeve gastrectomy on micronutrients status.

Methods: Our prospective study included 48 morbidly obese patients undergoing laparoscopic sleeve gastrectomy (LSG), with a mean age of 39.1 years and mean BMI: 43.5 kg/m². Serum level for nutritional parameters were evaluated: 25OHvitamin D, Vitamin B12 and folic acid.

Results: Baseline evaluation/6 months post-bariatric surgery (available for 16 patients):

Correction for de nutritional deficiencies was realised, and supplementation continued after the bariatric procedure.

• Mean level of Vitamin B12 was stable: 326 pg/ml at baseline and 298.5 pg/ml at the 6 months follow-up; Vitamin B12 deficiency (<193 pg/ml) was found in 7/47(14.9%) patients and 6 months post-bariatric surgery evaluation showed persistent deficiency in 2/16 patients (12.5%);

• Mean level of Folic acid at baseline: 5.88 ng/ml was maintained in the normal range (N>3 ng/ml) with minimal reduction at the 6 months evaluation: 4.43 ng/ml; Folic acid deficiency was objectified in 5/48 cases (10.4%) and was persistent in 1/16 patients (6.25%)

• The initial evaluation:average 25-hydroxy vitamin D (25OHD) level=16.75 ng/ml with significant correction to 20.78 ng/ml at the 6 months follow-up; Vitamin D insufficiency (<30 ng/mL) and vitamin D deficiency (<20 ng/mL) were present in in 28/31 patients (90.32%) respectively in 22/31 patients (70.96%); The prevalence of vitamin D insufficiency and deficiency were significantly improved to only 8/15(53.33%) and 6/15(40%) patients.

Conclusions: The level of nutrients was maintained at normal mean levels after sleeve gastrectomy and our preliminary data show the correction of nutrient deficiencies in most of the cases were possible in a short follow-up term (6 months).