ECE2016 Eposter Presentations Obesity (69 abstracts)
Is Pentraxin 3 a marker in pathogenesis of central obesity?
Ozen Dedeoglu 1 , Guzin Yaylali 2 , Fulya Akin 2 , Senay Topsakal 2 , Suleyman Demir 3 & Hande Senol 4
1Pamukkale University, Department of Internal Medicine, Denizli, Turkey; 2Pamukkale University, Department of Endocrinology, Denizli, Turkey; 3Pamukkale University, Department of Biochemistry, Denizli, Turkey; 4Pamukkale University, Department of Biostatistics, Denizli, Turkey.
Introduction: Pentraxin 3 (PTX3) is an acute-phase protein that shares structural homology with C-reactive protein (CRP). PTX3 is produced in macrophages, endothelial cells, and adipocytes in response to inflammatory stimuli, whereas hepatocytes are the main source of CRP. Because obesity and metabolic syndrome (MetS) are considered chronic inflammatory states, PTX3 might be involved in the pathogenesis of obesity and MetS as well as CRP. In this study, we aimed to investigate the relationships between PTX3, CRP, neutrophil-to-lymphocyte ratio (NLR) and BMI.
Methods: 86 obese premenapousal women (aged 17–55 years) and 56 women with normal BMI took part in this study. Antropometric measurements including waist circumferences (WC) were done. Serum concentrations of plasma fasting glucose, insulin, Pentraxin 3, CRP, complete blood count were measured. NLR was calculated. HOMA-R is also calculated to determine insulin resistance.
Results: PTX3 and NLR were similar in both groups. PTX3 and NLR were also similar in obese patients with or without insulin resistance. CRP is significantly higher in obese patients (P < 0.01). It was also significantly higher in insulin resistance obese patients (P < 0.01). There was’nt any correlation between BMI or any of the inflamatory markers. Multiple regression analysis showed that PTX3 is correlated with WC.
| Obese | Control | P | |
| PTX3 (Pentraxin 3) (pg/mL) | 0.83 | 0.86 | 0.887 |
| CRP (C-reaktive protein) (mg/dL) | 0.68 | 0.38 | 0.000 |
| Neutrophil (K/uL) | 4.5 | 4.1 | 0.039 |
| Lmphocyte (K/uL) | 2.3 | 2 | 0.001 |
| Neutrophil lymphocyte ratio | 2 | 2.1 | 0.492 |
Conclusion: Although PTX3 levels were not determinative in obese patients and has no correlation with body fat, it may have a relation with central obesity. To clarify this further studies are needed.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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