ECE2016 Eposter Presentations Neuroendocrinology (43 abstracts)
Liraglutide restores the endocrine function of islet’s β-cells and the altered lipid profile in early stages of life induced by food restriction in pregnancy
Yolanda Diz-Chaves , Laura Toba , Juan Fandiño , Hugo Ogando , María González-Núñez , Marina Romaní , Eva Vigo , Lucas González-Matías & Federico Mallo
University of Vigo, Vigo, Spain.
Maternal food restriction during late pregnancy and lactation, increases the risk of glucose intolerance and metabolic diseases such as diabetes & obesity in rats. Liraglutide is a GLP-1 receptor agonists administered for treating DM2. The aim of this study was to elucidate if liraglutide given to pregnant rats may prevent the deleterious effects of malnourishment in male pups analyzed at 21 days of age.
Twenty eight Sprague-Dawley pregnant rats were included. Controls (CT) were fed ad libitum, whereas dams in restricted group were fed with 50% (50FR) daily intake of control dams. Pregnant rats were treated with liraglutide (100 μg/Kg/12 h; 50FR/LIR, CT/LIR) or vehicle (50FR/VEH, CT/VEH) from gestational day 14 to 21.Pups body weight were controlled after birth. During lactation the FR was reduced to 30%. At 21 days of age (D21) and before weaning, pups were sacrificed. Serum and tissue samples were obtained and stored at -80°C until analysis.
50FR pregnant dams, gained 16% less body weight than controls, independently of the treatment with liraglutide. After birth, 50FR/VEH and 50FR/LIR male pups exhibited significantly decreased body weight at postnatal day 1, 7, 14 and 21 compared to CT/VEH. At D21, intraperitoneal fat pad is decreased in pups from FR-dams, without differences in mesenteric & gonadal fat pads nor adrenal glands’ weight. 50FR/VEH males displayed significantly decreased plasma lipid profile (TG, LDL-HDL-total cholesterol). Glycaemia trends to be increased by FR, but not differences were observed. However, 50FR/VEH group had increased peptide-C levels compared to CT/VEH, and LIRA reverted the effect of FR. LIR treatment increased lactate plasma levels just in 50FR males.
In conclusion, LIR restores the endocrine function of islet’s β-cells and the altered lipid profile induced by FR in pregnancy in early stages of life
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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