ECE2016 Eposter Presentations Growth hormone IGF axis - basic (12 abstracts)
Acromegaly and Dyslipidemia
Havva Keskin 1 , Kenan Çadırcı 2 , Yasemin Kaya 3 , Şenay Durmaz 4 , Abdulmuttalip Arslan 2 , Faruk Yıldız 2 , Hakan Gözcü 2 , Hakan Sevimli 2 , Mehmet Emin Budak 2 & Ayşe Çarlıoğlu 2
1Department of İnternal Medicine, Medeniyet University, Göztepe Training and Research Hospital, Istanbul, Turkey; 2Department of İnternal Medicine, Erzurum Training and Research Hospital, Erzurum, Turkey; 3Department of İnternal Medicine, Ordu University, Ordu, Turkey; 4Department of İnternal Medicine, Kırıkkale University, Kırıkkale, Turkey.
Aim: The risk of cardiovascular mortality is high in patients with acromegaly. In this study, we intent to evaluate serum lipid profile in patients newly diagnosed with acromegaly and determine its association with increased growth hormone (gh) and insulin like growth factor-1 (igf-1) levels.
Material and method: This study includes 57 patients newly diagnosed with acromegaly in our hospital (mean age 44.1±13.8 years; mean bmi 29.6±5.4 kg/m2) and 31 persons in control group who have similar age and bmi (mean age 38.8±15.4 years; mean bmi 26.9±7.3 kg/m2). None of the patients were on antilipemic drug. All venous blood sampling were taken for gh, igf-1, triglycerides (tg) and hdl-c, ldl-c were taken in 12 hours fasting state.
Findings: In our results, we statistically detected a significant difference in ldl level (mean ldl-c levels 140.2±61.3 mg/dl in acromegaly group vs. 115.6±30.4 mg/dl in control group, respectively, P=0.029), triglyceride level (mean tg levels 137.6±84.0 mg/dl in acromegaly group vs. 102.9±43.0 mg/dl control group, respectively, P=0.027) and hdl level (mean hdl levels 41.5±10.5 mg/dl in acromegaly group vs. 50.5±10.6 mg/dl in control group, respectively, P=0.001) between the patients with acromegaly and the control group. It was found a positive correlation between gh and ldl-c (r=0.375, P=0.02) and tg (r=0.302, P=0.01). There was also a significant positive correlation between igf-1, ldl-c (r=0.295, P=0.01) and tg (r=0.476, P=0.0001). Additionally, it was determined a significant negative correlation between gh - hdl (r=−0.399, P=0.001) and igf-1 - hdl (r=−0.310, P=0.01).
Results: In conclusion, growth hormone and igf-1 increase may be establishing a ground for atherosclerotic heart diseases by leading to proatherogenic lipid profile in patients with acromegaly. Therefore, it might be important to follow closely lipid levels in acromegaly monitorization.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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