ECE2016 Eposter Presentations Female Reproduction (42 abstracts)
Endocan as a novel biomarker to evaluate cardiovascular risks in Polycystic Ovary Syndrome
Mahmut Apaydin 1 , Selvihan Beysel 1 , Mustafa Caliskan 1 , Muhammed Kizilgul 1 , Ozgur Ozcelik 1 , Seyfullah Kan 2 , Mustafa Ozbek 1 , Erman Cakal 1 & Tuncay Delibasi 3
1Diskapi Teaching and Research Hospital, Ankara, Turkey; 2Ankara Teaching and Research Hospital, Ankara, Turkey; 3Kastamonu University School of Medicine, Kastamonu, Turkey.
İntroduction: Polycystic ovary syndrome (PCOS) is associated with risk of cardiovascular disease (CVD). Endocan is potential immunoinflammatory and endothelial dysfunction marker that may be linked to CVD. This study aimed to evaluate the risk of CVD in PCOS patients and to identify the novel biomarker for CVD risk.
Material and methods: We analyzed 52 premenopausal women with PCOS and 59 healthy controls. Clinical, biochemical parameters and endocan were analysed.
Result: Ferriman Gallwey score, BMI, waist-hip ratio, HOMA-IR, total testosteron were significantly higher in PCOS than controls. Serum endocan levels were significantly higher in the PCOS compared with the controls (457.19±239.32 vs 356.85±183.48 ng/ml, P=0.015, respectively) (Table 1).
| Controls | PCOS | P | |
| Age (years) | 25.93±5.22 | 23.46±5.31 | 0.015 |
| BMI (kg/m2) | 22.56±3.23 | 26.90±5.69 | 0.001 |
| Waist-hip ratio | 0.77±0.66 | 0.85±0.54 | 0.012 |
| Ferriman Gallwey Score | 6.89±0.97 | 15.11±5.60 | 0.001 |
| Glucose (mg/dl) | 78.44±8.57 | 81.37±7.71 | 0.652 |
| HOMA-IR | 1.80±0.93 | 3.53±2.61 | 0.001 |
| Total testosteron (pg/ml) | 29.96±9.26 | 66.45±27.26 | 0.001 |
| Endocan (ng/ml) | 356.85±183.48 | 457.19±239.32 | 0.015 |
Conclusion: Endocan is a potential inflammatory and CVD biomarker in PCOS. Further studies are needed to assess the relevance of endocan in CVD risk of PCOS.
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Endocrine Abstracts
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