ECE2016 Eposter Presentations Female Reproduction (42 abstracts)
Increased level of serum irisin concentration and its regulation by hyperinsulinemia in women with polycystic ovary syndrome
Agnieszka Adamska 1 , Monika Karczewska-Kupczewska 2, , Adamska Lebkowska 1 , Robert Milewski 4 , Maria Gorska 1 , Elzbieta Otziomek 3 , Agnieszka Nikolajuk 2, , Slawomir Wolczynski 5 , Marek Straczkowski 2, & Irina Kowalska 1
1Department of the Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland; 2Department of Metabolic Diseases, Medical University of Bialystok, Bialystok, Poland; 3Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland; 4Department of Statistics and Medical Informatics, Medical University of Bialystok, Bialystok, Poland; 5Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Bialystok, Poland.
Background: Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance.
Objective: The aim of the present study was to determine the relationship between serum irisin concentration and insulin sensitivity (Mffm) as well as the effect of insulin infusion on circulating irisin levels in PCOS women as compared with healthy controls.
Subjects and methods: Seventy seven women were enrolled in the study - 57 with PCOS and 20 healthy controls matched for BMI and age. Hyperinsulinemic euglycemic clamps were performed in all of the study participants. The serum concentrations of irisin at baseline and after the clamp, as well as changes of serum irisin concentration in response to insulin supplied during the clamp (Δ irisin), were estimated.
Results: The mean serum concentrations of irisin achieved at baseline and after hyperinsulinemia were higher in PCOS women in comparison to the control group (P=0.01; P=0.006, respectively). Insulin infusion resulted in a decrease of serum irisin concentration only in the PCOS group (P=0.007). In the control group, Δ irisin positively correlated with Mffm (r=0.56, P=0.009). In the entire group, multiple regression analysis showed that Δ irisin (β=0.70, P=0.0002), FFAs 60’ during the clamp study (β=−0.22, P=0.01), SHBG (β=0.54, P<0.0001) and the interaction between Δ irisin and PCOS (β=−0.67, P=0.0004) were significantly associated with Mffm.
Conclusion: An increase in serum irisin concentration at baseline and an inappropriate change in response to insulin infusion might be secondary to insulin resistant conditions in PCOS women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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