Endocrine Abstracts

Introduction: Polycystic Ovary Syndrome is the most common recognized endocrinopathy in women. The syndrome is often accompanied by obesity and insulin resistance.

Aim: The aim of the study was to assess the differences between the selected anthropometric and biochemical parameters in a group of women with insulin resistance and without insulin resistance.

Materials and methods: The study included a group of 45 women diagnosed with Polycystic Ovary Syndrome based on of the 2003 Rotterdam criteria. Insulin resistance was assess with HOMA-IR index. In accordance with the guidelines of the European Group for the Study of Insulin Resistance, we adopted HOMA-IR <2 as the valid values. Body composition was measured with TANITA BC-420 Analyzer. We assumed a significance level α=0.05.

Results: Insulin resistance has been recognized in 57.1% of women. Significant differences were found between the group of women with insulin resistance (average value of HOMA-IR=3.37±1.44) and the group of women without insulin resistance (average value of HOMA-IR=1.26±0.44) in terms of average values of: body mass (kg) (83.90±17.06 vs 64.38±14.66; P=0.0004), BMI (kg/m²) (30.62±6.37 vs 24.20±5.57; P=0.0015), body fat (%) (39.41±8.15 vs 29.64±8.29; P=0.005), visceral fat (6.63±3.21 vs 3.33±2.66; P=0.0011), HDL cholesterol (mg/dl) (54.96±13.35 vs 66.72±17.56; P=0.0193), SHGB (nmol/l) (36.64±21.09 vs 71.28±33.48; P=0.0008), insulin (uU/ml) (14.78±6.06 vs 6.70±2,68; P<0.0001) and FAI index (7.53±4.19 vs 3.43±2.85; P=0.0028).

Conclusion: In the group of insulin resistant patients, the percentage of body fat and visceral fat were higher. Insulin resistance was also associated with differences in the studied biochemical parameters.