ECE2016 Eposter Presentations Female Reproduction (42 abstracts)
Baseline and metoclopramide induced plasma prolactin level in lean PCOS women according to their FAI phenotype
Sandra Mrozinska 1 , Katarzyna Gorztyla 2 , Agnieszka Przywara 3 , Justyna Guzik 4 , Marta Kialka 5 & Tomasz Milewicz 5
1Department of Metabolic Diseases, Jagiellonian University, Medical College, Cracow, Poland; 2Department of Neurology, Medical Center, Lancut, Poland; 3Department of Oncology, Provincial Specialistic Hospital, Rybnik, Poland; 4St. Rafal’s Hospital, Cracow, Poland; 5Department of Gynecological Endocrinology, Jagiellonian University, Medical College, Cracow, Poland.
Aim: Aim of our study was to compare: the baseline and metoclopramide induced prolactin plasma level between PCOS women with FAI <5 phenotype (group A)(FAI, total testosterone divided by sex hormone biding globulin, whole multiply by 100) and PCOS women with FAI>5 phenotype (group B).
Patients and methods: The study population consisted of 354 lean women with PCOS. In all the patients the prolactin level at 02:00 h, 08:00 h and during the metoclopramide oral test, were assessed. The free androgen index was calculated to each woman. The population was dived into two group according to the FAI phenotype. The group A contains 250 women with PCOS and FAI>5, the group B contains 104 women with PCOS and FAI<5. The groups did not differ in age (group A: 24.3±5.3 years vs. group B 25.4±5.7 years and BMI (group A: 21.3±2.1 kg/m2 vs. group B: 20.9±2.1 kg/m2 at baseline.
Results: The prolactin level was statistically significant higher (P<0.0001) in group B at 02:00 h (55.2 uIU/ml vs. 98.7 uIU/ml), at 08:00 h (159.8 uIU/ml vs. 390.2 uIU/ml), at 60-minute of metoclopramide test (690.41 uIU/ml vs. 1853.5 uIU/ml) and at 120-minute of metoclopramide test (606.4 uIU/ml vs. 1328.2 uIU/ml). The prolactin ratio at 120-minute of metoclopramide test to the baseline level was also higher in the group B (11.1±6.5 vs. 14.7±10.2; P<0.001).
Conclusion: The results may suggest that prolactin levels are lower in women with PCOS and FAI>5 than in women with PCOS and FAI<5. The prolactin level in PCOS women may be connected with the level of androgenicity in PCOS women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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