ECE2016 Eposter Presentations Female Reproduction (42 abstracts)
Androgen distribution in different phenotypes of women with polycystic ovary syndrome (PCOS)
Dusan Ilic 1 , Ivana Bozic-Antic 1 , Jelica Bjekic-Macut 2 , Danijela Vojnovic-Milutinovic 3 , Tamara Bogavac 1 , Bojana Popovic 1 , Tatjana Isailovic 1 , Valentina Elezovic 1 , Sanja Ognjanovic 1 , Olivera Stanojlovic 4 , Svetozar Damjanovic 1 & Djuro Macut 1
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinial Center of Serbia, Belgrade, Serbia; 2CHC Bezanijska kosa, Belgrade, Serbia; 3IBISS, University of Belgrade, Belgrade, Serbia; 4Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: Polycystic ovary syndrome (PCOS) phenotypes A and B are considered to be more hyperandrogenic in comparison to phenotypes C and D that are considered to be mostly reproductive. The aim of this study was to analyze distribution of androgens in different phenotypes in our PCOS population.
Methods: We evaluated 365 PCOS women (PCOS:25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 healthy women (Controls: 25.41±5.16 kg/m2; 30.35±5.62 years). PCOS group was divided into 4 phenotypes: A [anovulation (ANOV), hyperandrogenism (HA), polycystic ovary morphology (PCOM)], B (ANOV, HA), C (HA, PCOM) and D (ANOV, PCOM). In follicular phase of menstrual cycle total testosterone (TT), SHBG, androstenedione and DHEAS and free androgen index (FAI) were determined in all subjects. All analyses were BMI and age adjusted.
Results: In comparison to Controls, phenotypes A, B and C had higher levels of TT, FAI, and androstenedione; DHEAS was higher in A and C, while SHBG lower in all phenotypes. Only 4% of phenotypes A, B and C had elevated only TT, which was significantly different in comparison to both D and Controls. Prevalence of elevated only DHEAS or androstenedione was the same in all phenotypes. The most common was presence of concomitantly high TT and androstenedione: A 23%, B 24%, C 15% while 0% in both D and Controls (P<0.05). A and C had higher prevalence of concomitantly high both TT and DHEAS (13% and 10%, respectively) in comparison to Controls (0%) and phenotype D (0%), (P<0.05). The prevalence of concomitantly elevated both androstenedione and DHEAS was the same in all groups.
Conclusion: In our PCOS population the most common hyperandrogenemia pattern is concomitant elevation of both TT and androstenedione. Low SHBG is a common feature in all PCOS phenotypes including phenotype D.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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