Endocrine Abstracts

Aim: The lipid accumulation product (LAP) index which is associated with abnormal glucose regulation can be easily calculated. Women with polycystic ovary syndrome have more than one risk factor for the development of cardiovascular diseases such as glucose intolerance, insulin resistance and abdominal lipoidosis. In this study, we intend the evaluation of LAP index in women with PCOS.

Method: This study included 35 women patients with PCOS (mean age 22.4±5.2 year) and 33 healthy normoovulatory women in control group who had similar age (mean age 21.0±3.1 year). The plasma lipid profile, glucose and insulin levels of the patients were detected after 12 h fasting and waist circumference was measured. The lipid accumulation product index was calculated with the formula previously defined as (waist circumference (cm) – 58) × triglycerides (mmol/l). HOMA IR glucose was calculated with the formula of (mmol/l)×insulin (μU/ml)/22.5.

Findigs: In this study, the mean of LAP index in the patients and the control group were respectively (38.2±42.6 and 12.0±13.1, P=0.000), TG (115.9±67.9 etc. 82.8±46.3 mg/dl, P=0.004), HOMA-IR (3.5±2.4 and 2.2±1.3 P=0.01), total cholesterol (178.2±35.4 and160.0±27.7 mg/dl P=0.02), insulin (16.1±10.1 and 11.0±6.3 μU/ml P=0.02), waist circumference (84.3±15.8 and 69.2±8.05 cm, P=0.000), LDL (107.1±31.1 and 88.7±27.1 mg/dl P=0.01).

There was a positive correlation between LAP index and bodyweight (r=0.79 P=0.000), waist circumference (r=0.81 P=0000) HOMA score (r=0.35 P=0.008), insulin (r=0.37 P=0.005), TG (r=0.79 P=0.000) and LDL levels (r=0.32 P=0.008).

A positive correlation was detected between BMI and LAP index (r=0.73 P=0.000), HOMA-IR (r=0.48 P=0.000), fasting insulin levels (r=0.46 P=0.000).

Results: High LAP index may help for the evaluation of metabolic risk in women with PCOS.