ECE2016 Eposter Presentations Female Reproduction (42 abstracts)
Serum alanine aminotransferase level as an early indicator of metabolic disturbancies in women with polycystic ovary syndrome (PCOS)
Jelica Bjekic-Macut 1 , Ivana Bozic-Antic 2 , Konstatinos Tziomalos 3 , Dusan Ilic 2 , Danijela Vojnovic-Milutinovic 4 , Olivera Stanojlovic 5 , Bojana Popovic 2 , Tamara Bogavac 2 , Tatjana Isailovic 2 , Valentina Elezovic 2 , Sanja Ognjanovic 2 , Djuro Macut 2 & Dimitrios Panidis 3
1CHC Bezanijska Kosa, Belgrade, Serbia; 2Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia; 3Department of Medicine, University of Thessaloniki, Thessaloniki, Greece; 4IBISS, University of Belgrade, Belgrade, Serbia; 5Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: Serum alanine aminotransferase (ALT) level is used to screen patients for unsuspected liver disease. The entire histologic spectrum of nonalcoholic fatty liver disease (NAFLD) can be seen in individuals with normal ALT values. Accordingly, it has been suggested that by using ALT>19 U/l, early stages of NAFLD could be detected. As it was established a relation of NAFLD and PCOS, the aim of our study was to compare metabolic characteristics of women with polycystic ovary syndrome (PCOS) in relation to ALT levels.
Methods: We evaluated 600 PCOS women diagnosed using ESHRE/ASRM criteria, divided into 2 groups: group A with ALT<19 IU/l (N=299; BMI 28.64±5.86 kg/m2; age 25.27±5.77 years) and group B with ALT ≥19 IU/l (N=301; BMI:32.64±7.36 kg/m2; age 25.93±6.12 years), and 53 healthy non-obese women (Controls: 24.05±3.29 kg/m2; 30.21±5.57 years). Serum liver enzymes, glucose, insulin, lipids, total testosterone and sex hormone binding globulin were determined. Insulin resistance was evaluated by homeostatic model (HOMA-IR). All analysis were BMI adjusted.
Results: In all examined subjects, liver enzymes were in the reference range. Group B had higher values of aspartate-aminotransferase (AST) (22.75±8.85 vs 16.73±3.60, P<0.001), gamma-glutamil-transferase (20.03±10.93 vs 13.40±5.80, P=0.009), alkaline phosphatase (78.52±21.36 vs 68.28±20.26, P<0.001), insulin (18.46±10.24 vs 13.48±8.83, P<0.001), HOMA-IR (4.52±2.78 vs 3.21±2.26, P<0.001), total cholesterol (5.15±1.02 vs 4.70±0.94, P<0.001), LDL (3.33±0.94 vs 2.97±0.82, P<0.001) and triglycerides (1.24±0.60 vs 0.97±0.40, P<0.001). There were no difference in fasting glucose, HDL, testosterone and SHBG.
Conclusion: Serum ALT levels greater than 19 IU/l could be an early indicator of metabolic disturbances in women with PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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