ECE2016 Eposter Presentations Female Reproduction (42 abstracts)
Glucose level after standard oral glucose tolerance test as a potential marker for the development of type 2 diabetes in women with polycystic ovary syndrome (PCOS)
Ivana Bozic-Antic 1 , Jelica Bjekic-Macut 2 , Dusan Ilic 1 , Danijela Vojnovic-Milutinovic 3 , Bojana Popovic 1 , Tamara Bogavac 1 , Tatjana Isailovic 1 , Valentina Elezovic 1 , Sanja Ognjanovic 1 , Olivera Stanojlovic 4 , Svetozar Damjanovic 1 & Djuro Macut 1
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia; 2CHC Bezanijska kosa, Belgrade, Serbia; 3IBISS, University of Belgrade, Belgrade, Serbia; 4Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: It has been shown that subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT), whose plasma glucose concentration does not return to their fasting plasma glucose (FPG) level within 2 h following standard oral glucose tolerance test (OGTT), have higher risk of progression into type 2 diabetes (T2D) than NFG/NGT subjects whose glucose returns to FPG level after OGTT. Although the development of T2D during the life of woman with polycystic ovary syndrome (PCOS) is nowadays assumed to be higher than previously thought, the exact reason for that is still unknown.
Methods: We evaluated 193 non-obese PCOS women (body mass index, BMI: 22.47±3.33 kg/m2; age: 24.93±4.59 years) diagnosed using ESHRE/ASRM criteria and 53 healthy non-obese women in control group (BMI: 24.05±3.29 kg/m2; age: 30.21±5.57 years). In follicular phase of menstrual cycle 2-h OGTT with 75 g of glucose was performed in all subjects. IFG, IGT and T2D were defined according to International Federation for Diabetes (IFD) criteria. All analysis were adjusted for BMI and age.
Results: None of the PCOS subjects had T2D and none of the controls had either IFG or IGT. In PCOS group, IFG was diagnosed in 3/193 (1.6%) and IGT in 6/193 (3.1%). All PCOS women with IFG had NGT, while all PCOS subjects with IGT had NFG. When only NGT/NFG subjects were analyzed (184 PCOS and 53 Controls), PCOS had higher prevalence of higher postload glucose than FPG in comparison to Controls (67% vs 50%, respectively P=0.045).
Conclusion: Higher postload glucose level than fasting plasma glucose level could be a useful marker of risk for the development of T2D in women with PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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