ECE2016 Eposter Presentations Female Reproduction (42 abstracts)
Follicular fluid Bisphenol A levels are higher and correlate negatively with the number of oocytes in women with tubal factor infertility compared to women with polycystic ovary syndrome
Georgios Boutzios 1, , Areti Mina 2 , Ioannis Papoutsis 3 , Sotiris Athanaselis 3 , Panagiotis Christopoulos 2 , Minas Mastrominas 4 , Eleni Kousta 2 & George Mastorakos 2
1Endocrine Unit, Department of Pathophysiology, Laiko University Hospital, Medical School, University of Athens, Athens, Greece; 2Endocrine Unit, Aretaieion University Hospital, Medical School, University of Athens, Athens, Greece; 3Department of Forensic Medicine and Toxicology, School of Medicine, University of Athens, Athens, Greece; 4Embryogenesis, Assisted Conception Unit, Athens, Greece.
Introduction: Bisphenol A (BPA) is a chemical compound found in a variety of everyday products. Exposure to BPA impacts negatively ovarian response, number of fertilized oocytes and implantation in women undergoing in vitro fertilization (IVF). The aim of the study was to determine BPA levels in women with polycystic ovary syndrome (PCOS) in comparison to women with tubal factor (TF) infertility who underwent IVF as well as to investigate their effect in critical endpoints of IVF such as number of oocytes and IVF outcome.
Material and Methods: Eighty two women in reproductive age (41 with PCOS and 41 normo-ovulatory with TF infertility) who underwent IVF were included in a prospective controlled study. A novel gas chromatography-mass spectrometry method was developed to determine BPA levels in serum, urine and follicular fluid (FF). Anthropometric, metabolic, and hormonal parameters were assessed.
Results: Higher BPA levels were detected in serum (0.780 ng/ml vs 0.580 ng/ml, NS) and FF (1.128 ng/ml vs 0.505 ng/ml, P<0.05) but lower in urine (0.985 ng/ml vs 1.500 ng/ml, P<0.05) of women with TF infertility compared to PCOS. There was a trend towards higher follicular BPA levels in TF women compared to PCOS women after BMI stratification. After adjustment for age, BMI and exogenous FSH administration, follicular BPA levels correlated negatively with number of oocytes collected during oocyte retrieval in TF (P<0.05) but not in PCOS women. Nevertheless, follicular BPA levels had no significant effect on fertilized oocytes fertilized and pregnancy rates in both groups.
Conclusion: The present study showed that there was a trend for higher BPA levels in FF of TF as compared to PCOS women. In TF women BPA FF levels correlated negatively with the number of oocytes collected during oocyte retrieval. However, no effect of FF BPA levels was observed on fertilized oocytes and pregnancy rates in both groups.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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