ECE2016 Eposter Presentations Endocrine tumours and neoplasia (68 abstracts)
Circulating levels of survivin in acromegaly
Esra Ademoglu 1 , Zehra Candan 2 , Suheyla Gorar 2 , Mutlu Niyazoglu 3 , Ayse Carlioglu 4 , Faruk Yildiz 5 , Idris Baydar 5 , Hakan Sevimli 5 & Abdulmuttalib Arslan 5
1Abant Izzet Baysal University, School of Medicine, Division of Endocrinology and Metabolism, Bolu, Turkey; 2Ankara Training and Research Hospital, Division of Endocrinology and Metabolism, Ankara, Turkey; 3Cerrahpasa Medical School, Division of Endocrinology and Metabolism, Istanbul University, Erzurum, Turkey; 4Erzurum Training and Research Hospital, Division of Endocrinology and Metabolism, Erzurum, Turkey; 5Erzurum Training and Research Hospital, Division of Internal Medicine, Erzurum, Turkey.
Introduction: Acromegaly is a chronic disorder characterized by chronic growth hormone (GH) excess. In most of cases, GH hypersecretion is derived from somatotroph cell tumors. Survivin is a member of apoptosis protein family, which was recently showed to be expressed in different benign and malignant human tumors. A number of studies showed overexpression of survivin in pituitary adenomas. This study is intended to determine circulating levels of survivin in patients with acromegaly.
Methods: The study group was composed of 19 newly diagnosed patients with acromegaly. Concurrently, 19 healthy individuals were included in the study as control group. Serum survivin levels, GH, insulin like growth factor-1 (IGF-1) and, some other biochemical parameters as fasting glucose, creatinine, alanine aminotransferase, cholesterol, triglyceride, highdensity lipoprotein cholesterol, lowdensity lipoprotein cholesterol were measured in each subject. Correlation analysis was performed between survivin and GH, IGF-1.
Results: Serum survivin levels tended to be higher in acromegaly group, but this was not reach statistical significance (P>0.05). Serum survivin levels were comparable among acromegaly patients and controls. Neither GH nor IGF-1 correlated with serum survivin.
Conclusion: Larger scale studies are needed concerning the circulating levels of survivin in patients with acromegaly.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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