ECE2016 Eposter Presentations Diabetes (to include epidemiology, pathophysiology) (83 abstracts)
How changed face of gestational diabetes mellitus within 12 years in Turkey
Nevin Dinccag 1 , Cemile Idiz 1 , Sevda Ozel 2 , Selda Gedik 1 , Nurdan Gul 1 , Fulya Turker 1 , Sakin Tekin 1 , Seher Tanrikulu 1 , Hülya Hacisahinoglu 1 & Ayse Uzum 1
1Istanbul University Endocrinology and Metabolism Department, Istanbul, Turkey; 2Istanbul University Biostatistics and Informatics, Istanbul, Turkey.
Backgrounds and aims: We aimed to determine final status of carbohydrate (CHO) intolerance of women with GDM who were followed between 3 months and 10 years after delivery.
Materials and methods: Two hundred and fourty participants with GDM history were enrolled into study and divided into two groups. [Group I: 40 women (38.0±6.3 years) who had delivery before 11±2 years ago, Group II: 200 women (34.0±5.1 years) who had delivery within 3–6 months]. Final status of a participants was evaluated with 75 g OGTT and compared the features of groups according to possible risk factors indicating CHO intolerance.
Results:
| Group I | Group II | P* | |
| n | 40 | 200 | |
| Age-at-gestation (yrs) | 28.7±5.7 | 34.0±3.1 | 0.001 |
| BMI (kg/m2) | 30.5±3.8 | 29.7±2.5 | 0.126 |
| Family history of DM (n) | 2.0±1.9 | 1.8±1.9 | 0.587 |
| Multiparity | 1.5±1.6 | 0.8±0.9 | 0.004 |
| At diagnosis A1C (%) | 5.0±1.0 | 5.5±0.5 | 0.093 |
| At diagnosis OGTT glucose (mg/dl) | |||
| Fasting | 100.8±23.5 | 93.6±11.8 | 0.148 |
| 1.st h | 212.6±44.4 | 198.6±26.9 | 0.036 |
| 2.nd h | 194.0±50.0 | 165.4±38.3 | 0.003 |
| 3rd h | 133±45.2 | 122.5±37.3 | 0.559 |
| Gestational week at diagnosis | 29.6±5.8 | 27.3±4.9 | 0.022 |
| Weight gain (kg) | 11.8±4.8 | 9.6±4.5 | 0.006 |
| Delivery time | 38.2±1.3 | 38.4±1.6 | 0.018 |
| Fetus of birth | |||
| Length (cm)/Weight (kg) | 50.2±2.4/3355.0±547.5 | 47.5±3.2/3181.6±543.5 | <0.001/0.033 |
| Head circumference (cm) | 36.0±5.9 | 34.7±5.6 | 0.250 |
| Final HOMA-IR | 2.8±1.7 | 1.4±1.1 | <0.001 |
| Final status of CHO tolerance n(%) | |||
| Normal/IFG+IGT/DM | 23 (57.5)/8 (20)/9(22.5) | 177(88.5)/19(9.5)/4(2.0) | |
Conclusions: In our country; as compared today, 12 years ago women used to became pregnant at younger ages but diagnosis was possible at later weeks of pregnancy, delivery time was early, maternal weight gain during gestation and fetal weight at birth were high. Postpartum follow-up of GDM after delivery is important. Although CHO intolerance normalizes soon after delivery in most women; it may sustain immediately after delivery and the frequency may be increased in the follow up years. Having multiparity and high BMI; obtaining high glucose levels at diagnosis, are crucial predictors of development of GDM but also we can conclude that the frequency of GDM increases as follow-up years after delivery increases.
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Endocrine Abstracts
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