ECE2016 Eposter Presentations Diabetes (to include epidemiology, pathophysiology) (83 abstracts)
Earlier development of diabetes mellitus type 2 as a consequence to psychological and physiological stress
Samrah Shaheen 1 , Maleeha Akram 1 , Sarwat Jahan 2 , Ghazala Kokab Raja 3 , Syed Ali Raza Kazmi 4 , Abida Raza 5 , Afzaal Ahmed Naseem 1 , Mazhar Qayyum 1 & Syed Shakeel Raza Rizvi 1
1Department of Zoology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, Pakistan; 2Department of Animal Sciences, Quaid-e-Azam University, Islamabad, Pakistan; 3University Institute of Biochemistry and Biotechnology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi, Pakistan; 4Aga Khan Health Centre, Rawalpindi, Pakistan; 5Nuclear Medicine Oncology and Radiotherapy Institute (NORI), Islamabad, Pakistan.
Diabetes mellitus type 2 (DM-2) is a disorder characterized by high blood glucose levels in the context of insulin resistance and relative insulin deficiency. DM-2 is typically an outcome of combinations of hereditary elements of impaired insulin release and insulin resistance, and natural variables like obesity, overeating, absence of activity, aging and stress. A number of hormones, such as cortisol and growth (GH), have insulin-antagonistic effects. Cortisol is a predominant biological marker of stress, whereas GH is released in response to stress. This study explored stress as a predisposing factor in causing DM-2 by determining psychological stress using depression, anxiety and stress scale, physiological stress by measuring plasma cortisol and GH through ECLIA and random blood sugar (RBS) levels by glucometer in 100 male and female DM-2 patients of 21–60 years and 100 age-matched controls. The level of psychological stress was moderate to severe in all age groups with significantly higher level in age groups of 21–30 and 31–40 years. The higher level of psychological stress corresponded well with higher level of physiological stress in terms of release of cortisol in patients of 21–30 and 31–40 years, although cortisol concentrations were higher in all groups compared to normal subjects. The higher level of psychological stress did not influence physiological stress much in terms of GH release, although GH concentrations were markedly but non-significantly higher in diabetic patients compared to control groups. The concentrations of cortisol and glucose were positively correlated in all age groups. The majority of patients was married, belonged to lower middle class, fell in normal BMI category, had diabetic mothers and exhibited higher RBS whether or not they exercised, followed diet plan or used oral medication. In conclusion, stress is one of the dominant factors resulting in development of type 2 diabetes mellitus in our local population.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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