Endocrine Abstracts

Status of carbohydrate metabolism in patients with primary hyperparathyroidism (PGPT) has been studied extensively in recent years, but the results of studies on the impact of long-term elevated levels of parathyroid hormone and hypercalcemia on the risk of type 2 diabetes continues to be in the discussion.

Objective: To study is to examine the prevalence of type 2 diabetes in patients with manifested and asymptomatic PGPT.

Materials and methods: General clinical examination of 136 patients with PGPT (note the presence of type 2 diabetes, available at diagnosis PGPT and developed in the period from diagnosis to surgical treatment PGPT), investigated parathyroid hormone, vitamin D and calcium.

Results: The asymptomatic PGPT reported in 54 patients (a mean age was 51.5±11.6 years), manifested PGPT - 82 patients (a mean age was 52±10.4 years). Type 2 diabetes is detected in 2 (3.7%) patients with asymptomatic PGPT and 12 persons (14.3%) with the manifested PGPT.

Significant differences was detected in the prevalence of type 2 diabetes in both groups of patients with PGPT (F=0.81, P<0.05).

Conclusion: The results of the study show an increasing prevalence of type 2 diabetes in patients with manifested PGPT compared with asymptomatic PGPT. The results may indicate the influence of long-term hypercalcemia and elevated levels of parathyroid hormone in the frequency of manifestation of type 2 diabetes in patients with PGPT.