ECE2016 Eposter Presentations Diabetes (to include epidemiology, pathophysiology) (83 abstracts)
The importance of gender difference in evaluation of relationship between MPV and serum biochemical parameters in type 2 diabetic patients
Yildiz Okuturlar 1 , Hakan Kocoglu 1 , Omer Seker 1 , Betul Erismis 1 , Bahar Ozdemir 1 , Meral Mert 2 , Sibel Ocak Serin 3 , Mehmet Hursitoglu 1 , Ozlem Harmankaya 1 & Abdulbaki Kumbasar 1
1Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, istanbul, Turkey; 2Department of Endocrinology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey; 3Umraniye Education and Research Hospital, Istanbul, Turkey.
Introduction: Increased mean platelet volume (MPV) is an independent risk factor for thromboembolism, stroke and myocardial infarction. In this study we tried to emphasize the importance of gender difference in evaluation of relationship between MPV and serum biochemical parameters in type 2 diabetic patients.
Methods: A total of 509 patients with diabetes mellitus who hospitalized due to several causes were retrospectively evaluated. Age, gender, other comorbidities, HbA1c, and other biochemical parameters were recorded. All data were analyzed by using SPSS 22.0 statistical package for Windows.
Result: A total of 509 patients consisted of 269 women and 240 men were included in this study. There was no difference in regard to other comorbidities between genders (P>0.05). Mean ages of women and men were 65.43±16.1 and 64.84±14.98 years, respectively (P=0.669). The mean MPV values of women and men were 8.61±1.40 and 8.52±1.47 fL, respectively (P=0.486). Erythrocyte sedimentation rate (ESR) (P=0.016), HDL-cholesterol (Chol) (P=0.024), total-Chol (P=0.01), and platelet (PLT) (P=0.035) levels were significantly higher in women whereas urea (P=0.08), creatinine (P=0.0001), and triglyceride (P=0.002) levels were significantly higher in men. There were positive correlations between MPV and urea, creatinine, uric acid, and PDW values and there were negative correlations between MPV and total-chol, LDL-chol, and PLT in women. Also there were positive correlations between MPV and HbA1c, glucose, uric acid, and PDW values and there were negative correlations between MPV and ESR and PLT values in men.
Conclusion: We did not find any difference in MPV values between male and female patients with diabetes. But we have showed that the significance of correlation analysis between MPV and each biochemical parameter depended upon gender. Thus the importance of gender difference in studies evaluating MPV levels in diabetic patients should be considered.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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