Endocrine Abstracts

Background and aims: Adipocytokines produced by adipose tissue cells, and their action is often systemic in nature. Connection of some adipocytokines (resisttin) with the development of autoimmune diseases such as type 1 diabetes (T1DM) is a perspective view. Therefore, the aim of study was to assess the association between adipocytokines (resisttin, adiponectin) and content of fat mass in T1DM.

Materials and methods: Ninety-five patients with T1DM (60 women, 35 males) (mean age: 30.6 (24.9–37.5) years, duration of DM: 13 (7–20) years, age of manifestation: 17 (12–23) years, HbA1c: 8,2 (7.6–8.9)%) and 55 (31 women, 24 men) controls. The research involved anthropometry of patients, general clinic examination, DEXA using a program ‘Body composition’. A fat mass index (FMI) was measured as total fat mass/height².

Results: There were no differences in the percentage of fat component in women with T1DM (34.5 (29.3–38.6) vs 32.6 (26.5–37.2); U=820; P=0.425) and men (21.3 (17.5–28.5)% vs 23.95 (15.8–26.6)%; U=385; P=0.865) compared with control groups. The trend was confirmed compare FMI- in women 7.36 (6.15–9.33) vs 6.68 (5.02–8.8) kg/m²; U=787; P=0.28; FMI in men 5.03 (3.26–6.55) vs 5.8 (3.37–6.79) kg/m²; U=378; P=0.641) in comparison to the control group. The patients with T1DM have significantly higher than the control levels of serum resistin – 0.46 (0.35–0.69) vs 0.37 (0.3–0.49) ng/ml; U=581; P=0.034. The contents of adiponectin in patients with T1DM comparable to healthy individuals (27.77 (27.1–28.42) vs 28.02 (27.38–28.4) ng/ml, U=790.5; P=0.847). There was medium negative correlation between serum levels of resistin and FMI (ρ=−0.48; P=0.004) in women with T1DM.

Conclusions: Elevated levels of resistin may be associated with the presence of an autoimmune process in the development of diabetes. Influence of the level of resistin on content of fat mass in patients with T1DM needs further study.