ECE2016 Eposter Presentations Diabetes (to include epidemiology, pathophysiology) (83 abstracts)
Diabetes and glycemic control in acute heart failure: complications, hospital stay and prognosis
Sílvia Paredes 1 , Melina Lopes 2 , Margarida Ramos-Lopes 1 , David Araújo 1 , Rosa Cardoso 1 , Ana Margarida Monteiro 1 , Teresa Pimentel 1 , Olinda Marques 1 & Marta Alves 1
1Hospital de Braga, Braga, Portugal; 2USF Maxisaude, ACeS Cávado I, Braga, Portugal.
Introduction: Few studies have evaluated the impact of type 2 diabetes on the prognosis of acute heart failure (HF). This study assessed the effect of diabetes and glycemic control on complications, hospital stay and prognosis in patients with acute HF.
Methods: Retrospectively, databases of 428 hospitalized patients by acute HF were analyzed, 201 diabetic patients and 227 controls. Statistical analysis was done using SPSS, considering statistical significance for P<0.05.
Results: Of all patients, 61.4% were female and the average age was 77.6±9.6 years. The median of hospital stay was 8 days (interquartil range (IQR) 8). Glycosilated hemoglobin (A1c) (median 7.2%; IQR 1.8) was available in 136 diabetic patients. The median of glucose was 177 mg/dl in the diabetic group and 119 mg/dl in controls. Glucose was higher in patients that had a posterior re-hospitalization for acute HF (P=0.034) and a negative correlation was found between the glucose value and the length of hospital stay (P=0.002). It was not found a significant difference in respect to complications, hospital stay, re-hospitalization and death in diabetic versus non diabetic patients. However, diabetic patients with an A1c<7% had a significant higher proportion of deaths compared to those with an A1c>7%.
Conclusion: At hospital admission, glucose seems to be related with the risk of re-hospitalization and the length of hospital stay in patients admitted for acute HF pointing out the need of an excellent glycemic control even in non-diabetic patients. The diagnosis of diabetes per se does not seem to be related with an adverse prognosis in acute HF. Nevertheless, a relative higher A1c seems to be related with a lower mortality in diabetic patients. These data call action to a thoughtful investigation in this area. Additionally, similarly to obesity and dyslipidemia, it raises the question of a possible diabetes paradox effect in patients with HF.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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