ECE2016 Eposter Presentations Diabetes complications (55 abstracts)
Sympathetic dysfunction in patients with diabetes revealed by task force monitor
Tanja Nisic , Milos Stojanovic , Miroljub Ilic , Drasko Gostiljac , Srdjan Popovic , Mira Stojkovic , Biljana Beleslin , Slavica Savic , Marija Barac , Tiana Lalic , Jasmina Ciric & Milos Zarkovic
Clinic of Endocrinology, Belgrade, Serbia.
Introduction: It is common that patients with diabetes have a dominant parasympathetic dysfunction.
Aim: Assessing the function of the autonomic nervous system in diabetic subjects.
Methodology: Task force monitor was used for testing at rest and passive orthostasis evaluating baroreceptor sensitivity (BRS), spectrum variability of RR-interval of high frequencies HF RRI which is linked to the parasympathetic, low frequency variability of diastolic blood pressure interval LF-DBP, partly linked to effects of sympathicus, LF HF RRI sympathovagal balance of RR interval. In the first group were 20 subjects with type 1 diabetes, age X 37 years, of which 12 men and eight women. The second group contained 25 subjects with type 2 diabetes, age X 62 years of which 18 men and seven women.
Results: In groups with type 1 diabetes LF HF at rest X 1.745 S.D. 0.91; LF HF orthostasis X 3.08 S.D. 2.65; LF DBP at rest X 44.79 S.D. 16:52; LF DBP orthostasis X 51.91 S.D. 11:41; HF RRI at rest X 36.01 S.D. 14.65; HF RRI orthostasis X 25.98 S.D. 8.2; BRS at rest X 10.1 S.D. 6.18. In the group with type 2 diabetes LF HF at rest X 4.01 S.D. 7.02; LF HF orthostasis X 4.7 S.D. 8.9; LF DBP at rest X 37.17 S.D. 14.85; LF DBP orthostasis X 37.32 S.D. 10.89; HF RRI at rest X 43.51; S.D. 17:48; HF RRI orthostasis X 43.51 S.D. 23:30; BRS at rest X 9.78 S.D. 6.50. Correlation between the groups showed highly significant difference for LF DBP in orthostasis (P<0.00067).
Conclusion: Significantly lower values of LF DBP were registered in the group with type 2 diabetes, which represents the ‘failure’ of sympathetic in orthostasis. Analyses revealed sympathetic dysfunction in patients with type 2 diabetes but not in subjects with type 1 diabetes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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