Endocrine Abstracts

Introduction: Diabetes Mellitus (DM) and prediabetic states (pre-DM) are well known risk factors for stroke. Admission blood glucose level and its control during hospital stay, help predicting arterial recanalization after thrombolysis and middle and long term prognosis. We analysed recurrence, mortality and nosocomial infectious complications in DM, pre-DM and patients without previous or newly diagnosed DM or pre-DM.

Methods: Descriptive analysis in consecutive patients with a diagnosis of stroke or transient ischemic attack (TIA) in our centre from 15th November 2013 to 14th may 2014. Descriptive and bivariate analysis were made.

Results: One hundred and sixty one patients were included - 66 DM (41%), 32 pre-DM (19.9%) and 63 normoglycemic (NG) patients (39.1%). Stroke etiology was cardioembolic in 42 (26.09%) patients (NG 30.16%, DM + pre-DM 23.47%; ns) and lacunar in 31 (19.25%) (11.11% normoglucémicos, 24.45% DM + preDM). During the following year, 17 patients (11.49% of those alive at discharge) suffered a recurrent stroke, affecting 15.38% patients with DM or pre-DM (14.75% DM; 16.67% pre-DM) and 5.45% normoglycemic patients (P<0.05). One-year mortality (14.91%) was higher among normoglycemics (19.05% vs 12.24%), as well as in hospital mortality (7.94% vs 6.12%) and infectious comorbidities during hospital stay (20.63% vs 14.29%), but none of them reached statistical significance.

Conclusions: As most studies in stroke recurrence, our series demonstrates a higher recurrence rate not only in diabetics but also in prediabetic patients. On the other hand, in-hospital and on-year mortality, and in hospital infections were more frequent among non-diabetic patients. The fact that DM is over represented in lacunar strokes as compared with cardioembolic strokes may have influenced these results, as mortality and severity are much higher in those with a known embolic source.