ECE2016 Eposter Presentations Clinical case reports - Thyroid/Others (71 abstracts)
Transient amenorrhea: a very rare complication of radioactive iodine ablation therapy for papillary thyroid carcinoma
Buket Yilmaz Bulbul 1 , Mehmet Celik 1 , Semra Ayturk 1 , Nuray Can 2 , Ebru Tastekin 2 , Atakan Sezer 3 , Funda Ustun 4 & Sibel Guldiken 1
1Department of Endocrinology and Metabolizm, Trakya University Medical Faculty, Edirne, Turkey; 2Department of Pathology, Trakya University Medical Faculty, Edirne, Turkey; 3Department of Surgery, Trakya University Medical Faculty, Edirne, Turkey; 4Department of Nuclear Medicine, Trakya University Medical Faculty, Edirne, Turkey.
Radioactive iodine (RAI) treatment has been used in the treatment of differentiated thyroid cancer (DTC) since 1946. RAI treatment is recently used as adjuvant treatment for ablation of residual tissue following thyroidectomy and in the treatment of metastases of thyroid cancer. Some acute (nausea, vomiting, ageusia, salivary gland swelling and pain) and long-term side effects (sialadenitis, pulmonary fibrosis, second primary malignancies) may be observed following RAI treatment. In 12–31% of young women, menstrual irregularities have been reported after high dose radioactive iodine treatment applied for the treatment of DTC. In this report, we presented two patients with DTC treated by RAI ablation, in whom transient amenorrhea had occurred. Basal FSH and LH levels elevated in these two patients within 3 months after RAI treatment, but all normalized within 6 months (table 1). We suggest that it is important to evaluate premenopausal patients with DTC for the development of RAI related menstrual irregularity and inform these patients for the possibility of treatment related ovarian dysfunction.
| Patient 1 | Patient 2 | ||
| Age | 42 | 41 | |
| RAI dose (mCi) | 100 | 150 | |
| 3 months after RAI | LH (1.9–12.5 IU/l) | 72.75 | 39 |
| FSH (2.5–10.9 IU/l) | 95.17 | 50.5 | |
| E2 (19.5–144.2 IU/l) | 2.19 | <5 | |
| 6 months after RAI | LH (1.9–12.5 IU/l) | 30.9 | 14 |
| FSH (2.5–10.9 IU/l) | 7.17 | 17 | |
| E2 (19.5–144.2 IU/l) | 130.61 | 128 |
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