Endocrine Abstracts

Late identification and inadequate assessment of cardiovascular risk factors are being considered as the main cause of high mortality in men with type 2 diabetes mellitus (T2DM).

Aim: To analyze the carbohydrate metabolism, levels of testosterone, proinflammatory cytokines in patients with T2DM and obesity.

Methods: We examined 123 men with T2DM and obesity (mean age – 53.8±6.8). Parameters of carbohydrate metabolism, total testosterone (T), leptin, C-reactive protein (CRP), e-selectin were analyzed.

Patients were divided into four groups: the 1st group included 41 patients with BMI 25–29.9 kg/m², the 2nd group – 51 patients with BMI 30–34.9 kg/m², the 3rd group – 23 patients with BMI 35–39.9 kg/m², the 4th group – 8 patients with BMI higher than 40 kg/m².

Data were analyzed using Mann–Whitney U-test for two independent groups.

Results: Statistically significant differences in the parameters of carbohydrate metabolism between groups were not found. The levels of T decreased as the increasing of BMI. Leptin level in the 1st group was 7.16[4.89; 19.7] ng/ml, in the 2nd – 11.13[7.75; 14.88] ng/ml, in the 3rd – 16.8[10.86; 27.59] ng/ml, and in the 4th – 27.68[20.15; 36.41] ng/ml (P<0.005). The CRP concentrations were statistically different in the 1st (4.49[2.06; 10.6] mg/l) and 4th (11.7[9.04, 13.95] mg/l) groups (P=0.006). The level of e-selectin in the 1st group was twice lower than in 4th (41.16[32.03; 64.77] ng/ml vs 81.2[46.1; 123.65] ng/ml) (P=0.02).

Conclusion: The excessive accumulation of adipose tissue leads to decreasing of T levels in men with T2DM. Increasing of leptin and CRP concentrations indicates the existence of systemic inflammatory process, which could be considered as an additional risk factor for cardiovascular disease in patients with T2DM.