Endocrine Abstracts

Aim: Recent studies have shown that immune responses contribute to atherosclerosis. The aim of this study was to investigate the relationship between carotid imt and the levels of anti-tpo in type 2 diabetic subjects with subclinical hypothyroidism (sch).

Subjects and methods: A total of 109 non-smoking diabetic subjects with sch were recruited for this study from June 2013 to May 2015. We used the analysis of variance to compare the differences of imt among the groups with different anti-tpo levels. Carotid imt was evaluated using high-resolution b-mode ultrasonography. Statistical analysis was performed by using spss 18 (P value <0.05 was considered significant).

Results: The mean age of the participants was 54.3±5.06 years with diabetes duration 4.6±3.21 years. A positive correlation was found between the mean of six segment carotid imt means and the levels of anti-tpo (r=0.58). Carotid imt levels were also significantly and positively associated with tsh, fpg and hba1c levels, whereas negatively with hdl-c. There were no statistically significant differences in the lipid profile and blood pressure levels between the groups with different anti-tpo levels.

Conclusion: In type 2 diabetic subjects with sch we found significant association between levels of anti-tpo and carotid imt. Measurement of thyroid antibodies can be useful risk factor for progression of carotid imt in type 2 diabetic subjects.