ECE2016 Eposter Presentations Cardiovascular Endocrinology and Lipid Metabolism (51 abstracts)
Free triiodothyronine is a predictor factor of left ventricular remodeling in patients after myocardial infarction and primary reperfusion assessed by means of two-dimensional speckle tracking echocardiography
Joanna Wierzbicka-Chmiel 2 , Artur Chmiel 1 , Grzegorz Koloczek 1 , Grzegorz Pifczyk 1 , Bogdan Marek 3 & Dariusz Kajdaniuk 3
1Department of Cardiology, Hospital Rybnik, Rybnik, Poland; 2Department of Endocrinology, Hospital Rybnik, Rybnik, Poland; 3Department of Pathophysiology and Endocrinology, School of Medicine in Zabrze, Medical University of Silesia, Zabrze, Poland.
Introduction: Left ventricular remodeling (LVR) is the most important consequence of acute myocardial infarction (AMI). The aim of the study was to assess the value of free triiodothyronine (fT3) in the prediction of LVR after AMI and primary coronary angioplasty (PCI).
Methods: Seventy patients (F/M=17/53, 61±11 years old) without recognized previous thyroid dysfunction and AMI were enrolled into the prospective observational study. Conventional and global longitudinal two dimensional speckle tracking echocardiography (LSTE) were performed 2 days (baseline) and 50 days after AMI. Thyroid function serum parameters (TSH, fT3, fT4) were measured three times: before, 2 and 50 days after catheterization. Patients were divided into two groups according to the change of LSTE at 50 days follow up (increase - I, decrease - II).
Results: At the baseline, both groups didn’t differ in terms of fT3 concentration (mean difference 0.13 pg/ml; P=0.4), left ventricular ejection fraction (54%±9 vs 51%±10; P=0.2) and global LSTE (−17%±4 vs −15%±4; P=0.1). The difference between fT3 level between 2 and 50 days after PCI was a significant predictor of the change of LSTE (group x time interaction P=0.015). According to the ROC analysis the increase of fT3 upper 0.28 pg/ml (sensitivity 69%, specificity 54%) was the most powerful predictor of the increase of LSTE after AMI.
Conclusion: The change of fT3 levels are closely associated with early LVR in patients with AMI and successful interventional treatment, hence might help to distinguish the patients endangered LVR.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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