Endocrine Abstracts

Background: Subclinical hypothyroidism is a thyroid disease which encountered in practice, commonly. Thyroid hormones affect metabolic syndrome parameters including HDL cholesterol, triglycerides, plasma glucose levels, blood pressure and abdominal obesity. Furthermore; there have been growing evidences about the relationship between vitamin D deficiency and autoimmune thyroid diseases. Therefore; we aimed to evaluate the association between the metabolic parameters and 25-OH-vitamin D levels in subclinic hypothyroid patients.

Methods: This study consisted of 110 patients (62 subclinical hypothyroid and 48 euthyroid) who attend to Haseki Training and Research Hospital’s Internal Medicine outpatient clinics between 2014 January and April. The groups were similar interms of age (51.66±14.64 in subclinical hypothyroid; 47.42±15.57 in euthyroid group; P=0.14). Serum fT₄, TSH, total cholesterol, trigliseride, LDL-C, HDL-C, fasting glucose and 25(OH)- vitamin D levels were recorded. Height, weight, waist circumference and blood pressure of all subjects were meaured.

Results: The 25-OH-vitamin D, fasting glucose, total cholesterol, triglycerides, HDL-C, LDL-C and waist circumference levels were similar between euthyroid and subclinical hypothyroid groups (P>0.05). The 25-OH-vitamin D level was 20.93±16.5 in subclinical hypothyroid group and 21.88±19.15 in euthyroid group. The increased BMI was found in subclinical hypothyroid group (P=0.024). Prevalence of metabolic syndrome was significantly higher in euthyroid group (43.5% in subclinical hypothyroid group, 25% in euthyroid group; P=0.044).

Conclusion: We found the lower vitamin D levels in subclinical hypothyroid group, however the difference did not reach statistical significance. Additionally, the higher metabolic syndrome prevalence is obtained in subclinic hypothyroidism.