ECE2016 Eposter Presentations Calcium and Vitamin D metabolism (61 abstracts)
Biochemical and hormonal alterations in women who underwent total thyroidectomy
Kassiani Kakava 1 , Symeon Tournis 2 , Georgios Papadakis 3 , Ioannis Karelas 1 , Pavlos Stampouloglou 1 , Evanthia Kassi 4 , Ioannis Triantafillopoulos 2 , Theodoros Karatzas 5 , Vassiliki Villiotou 6 , Nikolaos Dogkas 6 , Pavlos Sarov 1 , Georgios Tassopoulos 1 & Nikolaos Petridis 1
1Head and Neck Surgery Department, Metaxa Anticancer Hospital, Pireaus, Athens, Greece; 2Laboratory of Research of Musculoskeletal System of the School of Medicine, University of Athens, Athens, Greece; 3Department of Endocrinology, Metaxa Anticancer Hospital, Pireaus, Athens, Greece; 4Endocrinology Unit, Laikon General Hospital, Athens, Greece; 52nd Propedeutic Surgical Department, Laikon General Hospital, Athens, Greece; 6Department of Biochemistry, Metaxa Anticancer Hospital, Pireaus, Athens, Greece.
Introduction: Postsurgical hypoparathyroidism, (postHypoP), is a common complication of total thyroidectomy. We studied the variation of biochemical and hormonal parameters in patients who underwent total thyroidectomy.
Design: The study included 106 females of a mean age (±S.D.) 51.03 (±13.42) years who underwent total thyroidectomy for multinodular goiter. We estimated the value of 25(OH)vitD, PTH, CT, adjusted Ca, P, and alkaline phosphatase (Alp), preoperatively and in the 1st and 7th postoperative day.
Results: The patients were devided in groups, A and B, based on the presence of postHypoP. A total of 67 patients experienced postHypoP and were included in group A and 39 without postHypoP in group B. Patients in group A were younger than patients in group B (49.6±14.1 vs 53.3±11 years, P=0.031). The presence of parathyroid tissue in biopsy was significantly related to postHypoP, as observed in 38.1% in group A vs 14.7% in group B (P=0.016). In contrast, malignancy or thyroiditis in histology were not significantly related to postHypoP.
When comparing laboratory values of groups A and B there was no statistically significant difference in preoperative values of Ca, PTH and 25 (OH) vitD between the two groups (P>0.05). The 1st postoperative day Group A had lower mean adjusted Ca levels (Ca: 8.29±0.43 vs 9.34±0.41 mg/dl, P=0.023). From the ROC curve, the best cut-off point of PTH in the 1st postoperative day that differentiated patients who developed postHypoP from those who did not was 13.45 pg/ml with sensitivity of 77% and specificity of 54%.(Area under the curve (AUC) =0.71, 95% CI=0.61–0.81, P<0.001).
Conclusion: In patients after total thyroidectomy a PTH value ≤13.4 pg/ml the 1st postoperative day and the presence of parathyroid tissue in biopsy are positive related to postHypoP.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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