Endocrine Abstracts

Background: One of the markers of bone metabolism is osteocalcin (OC) and Its elevated level indicates osteoporosis.

Objective and hypotheses: We investigated the OC level in 14 girls with TS (45,X (n=8), 45,X/46,XX (n=3), structural abnormalities of chromosome X (n=3): seven patients at 4–11 year and 7 – at 12–18 year.

Method: DEXA (Z-score, S.D.), serum levels of OC, FSH, LH, estradiol.

Results: We observed violations of bone tissue by DEXA at 76.87% girls with TS: namely the osteoporosis - at 30.66%, osteopenia - at 46.21%. Mean OC levels did not differ significantly in girls with TS, aged 4–11 year (98.59±41.11 ng/ml) and 12–18 year. (91.98±51.83 ng/ml, P>0.05), but were higher than children in control age group: 46.23±12.43 ng/ml (P<0.05), and 51.12±22.64 ng/ml (P<0.05), respectively. No significant differences were found of OC level in patients with different karyotype: 45,X - 102.00±36.62 ng/ml, 45,X/46,XX- 53.92±46.04 ng/ml and structural abnormalities of chromosome X-117.59±55.30 ng/ml (P>0.05). No statistically significant association was found of OC level with the content of FSH, LH, estradiol, the degree of bone metabolism (Z- score). At the same time the OC level was higher than the age normal in 60.03% of TS girls over 12 years, and was normal in all patients 4–11 yrear. OC level was elevated in 100% patients with osteoporosis (Z- score > (−)2.5 S.D.) and in 75.0% - with osteopenia (Z-score of (−) 1.0–2.5 S.D.).

Conclusion: The level of the OC in girls with TS was not dependent on its age, karyotype and content of sex hormones. In 71.43% of all girls with TS and in 100.0% with osteoporosis OC level was higher than the normal age indices. Research OC should be carried out to all girls with TS for early detection of osteoporosis and holding his treatment.