Endocrine Abstracts

Introduction: Women with Turner syndrome (TS) are known to be at risk of decreased BMD (dBMD). Sex hormone replacement therapy is crucial to ensure the proper BMD formation, although the dBMD remains a problem in TS.

Aim: To investigate the prevalence of decreased bone mineralization and it’s association with hormone levels in TS.

Subjects: Women with geneticaly confirmed TS aged ≥ 18 year.

Methods: There were 53 women with TS enrolled into the prospective study. To assess the BMD dual – energy – X-ray absorptiometry (DEXA) parameters were analysed. Z-score ≤ −2.0 S.D. was defined as dBMD (International Society for Clinical Densitometry guidelines). The lowest value of Z-score in the spine or in the neck of femur was included into the analysis. The correlations between BMD and the levels of Testosterone (T), Estradiol (E), Thyroid stimulating hormone (TSH), calcium (Ca+), ionized calcium (Ca2+), body mass index (BMI), final height (FH), the duration of E use (DE), were assessed.

Results: Mean age of participants was 29.06±7.19 year. Mean FH was 152.33±6.21 cm, mean weight 57.19±11.40 kg, (mean BMI 24.59±4.82 kg/m²), mean BMD was 0.787±0.144 g/cm². dBMD was diagnosed in 26.5% (n=13) of TS, normal BMD was found in 73.5% (n=36). The significant correlation between BMD and BMI was observed (r=0.309, P=0.039). The significant negative correlation between DE and Ca+ (r=−0.317, P=<0.05) was found. There was no correlation between BMD and T, E, TSH levels.

Conclusions: BMI has positive effect on BMD in TS patients. No relationship between sex hormone, TSH, calcium concentrations and BMD was identified in this study.