Endocrine Abstracts

Introduction: Osteoporosis is a metabolic disease characterised by reduction of the bone mass density and deterioration of architecture of the bone and its strength. Continuous process of modeling and remodeling of bones is regulated by action of numerous circulating hormones. Fracture risk makes osteoporosis clinically important disease.

Goal of this study was to examine thyroid dysbalance, parathormone secretion disorder as risk factors for osteoporosis in elderly.

Description of methods: Study involved 195 participants aged 65 or more. Dual photon absorbtiometry (DXA), to confirm osteoporosis. PTH disorder was found in 58%, and thyroid disorder in 30% participants. Linear correlation was used as a statistical method to correlate variables.

Result: PTH levels (84.56 pg/ml±3.76) and decreased T-score levels showed high statistical significance (P<0.01), linear correlation coefficient (r), −0.94. DXA Z-score (−1.42 S.D.±0.05) and PTH level (84.56 pg/ml±3.76) also showed high significant correlation (P<0.01, r=−0.82). Decreased TSH levels significant correlated with decreased bone mineral density. Correlation was greater in elderly with hypothyreosis.

Conclusion: Thyroid disbalance and parathormone secretion disorder are common in elderly with osteoporosis

Keywords: Osteoporosis, elderly, parathormone, thyroid hormone