ECE2016 Eposter Presentations Bone & Osteoporosis (40 abstracts)
The influence of osteoporosis and cardiometabolic syndrome risk factors on bone mineral density in females with thyroid dysfunction
Zoran Gluvic 1, , Vladimir Samardzic 1 , Milena Lackovic 1 , Jelena Tica Jevtic 1 , Marina Vujovic 1 , Vesna Popovic-Radinovic 1 , Bojan Mitrovic 2 , Marija Popin-Taric 3 , Anita Vasic-Vlaisavljevic 3 & Esma R Isenovic 4,
1Zemun Clinical Hospital, Department of Endocrinology and Diabetes, School of Medicine, University of Belgrade, Belgrade, Serbia; 2Zemun Clinical Hospital, Medical Intensive Care Unit, School of Medicine, University of Belgrade, Belgrade, Serbia; 3Zemun Clinical Hospital, Department of Geriatrics, School of Medicine, University of Belgrade, Belgrade, Serbia; 4Vinca Institute of Nuclear Sciences, Lab for radiobiology and molecular genetics, University of Belgrade, Belgrade, Serbia; 5The Pharmaceutical Research Institute at Albany, Albany College of Pharmacy and Health Sciences, New York, New York, USA.
Introduction: The effects of TSH and thyroid hormones on bone turnover are well-known. The aim of this study is to examine the influence of osteoporosis (Op) and cardiometabolic syndrome risk factors on bone mineral density (BMD) in the population of age-matched, normotensive and nondiabetic females.
Material and methods: Cross-sectional study involved 76 females (average age 53±10 years), divided into three groups: hypo-, hyper-, and euthyroid. Presence of smoking habit, previous fracture/s and menopause were Op risk factors while body mass index (BMI), waist circumference (WC), triglycerides, and cholesterol levels were cardiometabolic risk factors. Index of cardiometabolic burden (ICMB) consisted of BMI >30 kg/m2 and/or WC >88 cm and showed increase in cardiovascular disease risk. Lumbar spine (LS) and left hip (LH) T-scores represented DEXA measured of BMD. Osteopenia and Op were defined as T-scores < −1.
Results: Decreased BMD was detected in 46 (60%) participants. The lowest T-scores were observed in hypothyroid group. Average LS and LH T-scores were −1.1 and −0.75 respectively, and differed between groups (hypo/hyperthyroid vs euthyroid). Significant influences of BMI and triglycerides on LH T-score as well as the presence of previous fractures and menopause on LS/LH T-scores were detected. The effect of TSH, FT4 and ICMB on BMD was not significant.
Conclusion: In the population of females with thyroid dysfunction on initial presentation, osteopenic BMD was registered. The presence of previous fractures and menopausis, BMI, and triglycerides significantly affected BMD, while TSH, FT4, and ICMB did not affect BMD.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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