ECE2016 Eposter Presentations Bone & Osteoporosis (40 abstracts)
Bone turnover markers in women with postmenopausal osteoporosis depending on the level of vitamin D
Jovanka Novakovic-Paro 1, , Tijana Icin 1, , Milena Mitrovic 1, , Dragana Tomic-Naglic 1, , Radoslav Pejin 1, , Djordje Popovic 1, , Ivana Bajkin 1, , Bojan Vukovic 3, , Damir Benc 1, , Milica Medic-Stojanoska 1 & Branka Kovacev-Zavisic 1,
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Vojvodina, Novi Sad, Serbia; 2Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia; 3Emergency Center, Clinical Centre of Vojvodina, Novi Sad, Serbia.
Introduction: It is indisputable importance of vitamin D for the preserved integrity of the skeleton and bone metabolism.
The aim of the study was to analyse bone turnover parameters in relation to the vitamin D status in women with postmenopausal osteoporosis.
Materials and methods: This study included a total of 195 postmenopausal women with osteoporosis. Osteoporosis is diagnosed by DXA scan of the spine and hip. Bone turnover markers osteocalcin, beta-crosslaps and 25OHD were determined by ECLIA method on Elecsys apparatus. Vitamin D status is defined as a deficiency if 25OHD <30 nmol/l. Within the range of normal values of 25OHD (30–100 nmol/l), insufficiency is defined if level of 25OHD is 30–75 nmol/l and a sufficient level of 25OHD >75 nmol/l.
Results: The mean age was 60.30±6.33 years and mean duration of postmenopausal period was 11.8±5.51 years. The average BMI was 25.41±4.26 kg/m2. The average value of 25OHD was 39.98±17.97 nmol/l, the average value of osteocalcin was 32.31±11.97 ng/ml and the average value of beta-crosslaps was 545.31±212.07 pg/ml. 25OHD level of <30 nmol/l in 59 (30.26%) subjects, the level of 25OHD 30–75 nmol/l had a 128 (65,64%), and vitamin D levels >75 nmol/l, had an 8 (4,10%) of subjects. There was a statistically significant difference in levels of osteocalcin and beta-crosslaps compared to the levels of vitamin D defined as a deficiency, insufficiency and sufficiency. Average values of osteocalcin in the above defined groups of vitamin D were 35.15±14.26 vs 31.49±10.77 vs 24.59±5.38 ng/ml; P<0.1. Average values of beta-crosslaps in the above defined groups of vitamin D were 584.16±230.77 vs 539.30±201.33 vs 354.88±128.33 pg/ml; P<0.01.
Conclusions: In women with postmenopausal osteoporosis dominates deficit and insufficient levels of vitamin D. Insufficient vitamin D leads to accelerated bone remodelling with a predominance of bone resorption over formation which contributes to the reduction of bone mass and quality.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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