Endocrine Abstracts

Introduction: Generally, symptoms of celiac disease is not accompanied when present together with autoimmune endocrine diseases. In this study, we aimed to investigate the prevalence of silent celiac disease in the APS and autoimmune monoglandular disorders by measuring tissue transglutaminase antibodies (ttgAb).

Methods: A total of 103 patients with monaglandular or polyglandular autoimmune endocrine disorders and 32 control subjects were enrolled in the study. At least the existence of two diagnoses with type 1 diabetes, Addison’s disease, autoimmune thyroid disease, vitiligo, pernicious anemia, hypoparathyroidism, gonadal failure were considered APS and patients with only one of those type 1 diabetes, Hashimoto’s thyroiditis or Addison’s disease were enrolled as monoglandular endocrine disease. Serum samples were collected from patients and were studied at one time for tissue transglutaminase antibodies.

Results: Hashimoto’s thyroiditis was present in the sixty-eight patients of 103 patients including OPS and monoglandular endocrine disease, type 1 diabetes was in the forty-four patients and Addison’s disease in the seventeen. In the 13 of 103 patients (12.6%) ttgAb IgA were positive and in the 8 of 103 (7.8%) ttgAb IgG were positive but in the healthy control group both IgA or IgG antibodies were not present. Highest rates of positive ttgAb IgA frequency was detected in the Addison’s disease with 29.4% (5/17). It was 13.6%, in the type 1 diabetes, 8.8% in the Hashimoto’s diasease and 16.7% in the APS. There were not observed statistically significant difference between the groups and the ttgAb IgG positivity was observed with lower rates.

Conclusion: The prevalence of silent celiac disease was higher in the patients with autoimmune endocrine disorders when compared with the healthy control group. The frequency of ttgAb is not not higher in the APS then monoglandular endocrine disorders and Addison’s disease likely has highest prevalence of silent celiac disease.