ECE2016 Eposter Presentations Adrenal cortex (to include Cushing's) (85 abstracts)
Do lipid profile predict subclinical Cushing’s Syndrome in patients with adrenal incidentalomas?
Gesthimani Mintziori , Thomas Georgiou , Athanasios Siolos , Fotini Adamidou , Zoe Efstathiadou , Panagiotis Anagnostis , Athanasios Panagiotou & Marina Kita
Department of Endocrinology, Ippokratio General Hospital, Thessaloniki, Greece.
Introduction: Adrenal Incidentalomas (AIs) have been associated with an increased risk of metabolic syndrome and dyslipidemia, though evidence regarding the latter is limited and, sometimes conflicting. Lipid abnormalities in patients with AIs have been described to be associated with subclinical hypercortisolism. Our aim was to test if lipid profile in patients with adrenal incidentalomas may predict subclinical Cushing’s Syndrome (sCS).
Material and methods: Ninety-four patients (n=94) with adrenal incidentalomas (AIs) were included in a prospective cohort study. All patients were followed up for three years and alternations of their hormonal and lipid profiles were recorded. IBM SPSS Statistics v20 were used.
Results: The 94 patients (25 men and 69 women) of our cohort harbored 111 AIs. There were no differences between patients with sCS and those without, with respect to their baseline lipid profile and blood pressure (systolic and diastolic). Non-HDL concentrations decreased over time (Repeated Measures ANOVA, P=0.013), despite patients’ Body Mass Index (BMI) remaining unchanged. Logistic regression revealed that the only predictor of sCS is the size of adrenal incidentalomas, as calculated by computed tomography (CT).
Conclusion: The current study demonstrated that lipid profile at baseline or during follow up cannot predict sCS in patients with adrenal incidentalomas. The improvement of patients’ lipid profile during follow up is probably due to better medical management.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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