Endocrine Abstracts

Cell immortalization has been considered for a long time as a classic hallmark of cancer cells. Besides telomere maintenance due to the ‘alternative mechanism of telomere lengthening’ it was advanced that such immortalization could be due to telomerase reactivation, but the mechanisms underlying such reactivation remained elusive.Mutations in the coding region of telomerase gene are very rare in the cancer setting, despite being associated with...

Paula Soares, BSc, MSc, PhD, is an Assistant Professor of Biopathology at the Medical Faculty of the University of Porto and coordinates the Group of Cancer Biology at the Institute of Pathology and Immunology of the University of Porto (Ipatimup) – Instituto de Investigação e Inovação em Sáude (i3S), Portugal. She received her degrees in Biology, Master in Oncobiology, and PhD in Human B...