BSPED2015 e-Posters Thyroid (10 abstracts)
Scottish mothers and babies at Yorkhill (MABY) thyroid health study – preliminary report
Filiz Mine Cizmecioglu 1 , Maira Bouga 2 , Suzanne Fletcher 2 , Sahar Sharif 2 , Guisella Velasquez 2 , Sarah Blaise 2 , Jeremy H Jones 3 , Malcolm Donaldson 2 & Emilie Combet 2
1Kocaeli University and Medical School, Izmit, Turkey, 2University of Glasgow, Glasgow, UK, 3Royal Hospital for Children, Glasgow, UK.
Introduction: Iodine is essential for thyroid hormones synthesis, and fetal/infant neurodevelopment. There is increasing evidence of iodine insufficiency among British women. The MABY study is a longitudinal cohort study assessing the iodine and thyroid status of pregnant women and their offspring.
Methods: Healthy women were recruited (target 697 mother/infant pairs) from antenatal clinics at gestational week (GW) 28±1. Blood and urine were collected at GW 28, 36; and from infant and mother postnatally (week 1). Optional maternal hair and breastmilk samples were collected. A validated iodine-specific food frequency questionnaire (FFQ) was completed at G28 and postnatally. Infant thyroid function was assessed through neonatal capillary TSH and urinary iodine status (UI) by Sandell-Kolthoff method.
Results: Over 6 months, 50% of eligible women approached were enrolled (n=191) (median age 33 years, IQR 30–35). Median (IQR) iodine intake at recruitment (100% FFQ completed) was 142 (94–112) ug/d, up to 191 (121–269) ug/day when iodine-containing supplements (reported by 37%) were included. Urine and blood samples were collected from 99 and 93% (GW28) and 94 and 93% (GW36), respectively. To date, 70 women have given birth, with 62 infants (40F:22M) followed-up (eight excluded based on GW, pregnancy complications or drop-out). Median (IQR) birthweight and gestational age were 3515 g (3275–3899) and 40+2 weeks (39+3–41+1). Postnatal maternal sample/data collection (n=62) was: 97% FFQ, 92% urine, 98% blood, 57% hair and 30% breastmilk. Infant urine and blood spots were obtained from 75 and 77%. Infant TSH results (n=60) showed four (7%) infants >2 mU/l, none >3 mU/l. Preliminary UI analysis indicated a maternal median (IQR) UI of 109 ug/l (54–189) at GW28 (n=58); 150 ug/l (93–231) at GW36 (n=53), and 58 ug/l (19–163) postnatally (n=53). Neonatal UI was 117 ug/l (64–188).
Conclusion: Enrolment and retention for the MABY study is encouraging with >25% of the target number recruited so far. Preliminary data are consistent with other iodine studies in the UK.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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