Endocrine Abstracts

Contents

• Plenary Lecturers’ Biographical Notes
• • Society for Endocrinology Starling Medal Lecture
  • • Hyperactive PI-3-kinase signalling without hormone excess: between cancer and endocrinology

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    • Society for Endocrinology Starling Medal Lecture

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  • Society for Endocrinology Medal Lecture
  • • Kisspeptin - a vital trigger of puberty with therapeutic potential

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    • Society for Endocrinology Medal Lecture

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  • Society for Endocrinology Transatlantic Medal Lecture
  • • An integrated view of nuclear receptor/chromatin interactions: From genome wide to real time molecular dynamics

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    • Society for Endocrinology Transatlantic Medal Lecture

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  • Society for Endocrinology Dale Medal Lecture
  • • Calcium regulation: from rhinos to molecules

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    • Society for Endocrinology Dale Medal Lecture

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  • British Thyroid Association Pitt-Rivers Lecture
  • • Abstract unavailable

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    • British Thyroid Association Pitt-Rivers Lecture

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  • Clinical Endocrinology Trust Lecture
  • • Mining the steroid metabolome in adrenal hormone excess

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    • Clinical Endocrinology Trust Lecture

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  • Clinical Endocrinology Trust Visiting Professor Lecture
  • • Confronting the last frontiers of endocrine hypertension

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    • Clinical Endocrinology Trust Visiting Professor Lecture

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  • Society for Endocrinology European Medal Lecture
  • • Repositioning mineralocorticoid receptor antagonists in renal diseases: pathophysiological basis and therapeutic implications

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    • Society for Endocrinology European Medal Lecture

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  • Society for Endocrinology International Medal Lecture
  • • Controlling the freedom of steroids in health and disease

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    • Society for Endocrinology International Medal Lecture

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• Society for Endocrinology Journal Awards
• • Society for Endocrinology Journal Award ‐ Journal of Endocrinology
  • • Potential biomarker of metformin action

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  • Society for Endocrinology Journal Award ‐ Journal of Molecular Endocrinology
  • • 1,25-vitamin D3 promotes cardiac differentiation through modulation of the WNT signaling pathway

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  • Society for Endocrinology Journal Award ‐ Endocrine-Related Cancer
  • • Aberrant DNA hypermethylation of SDHC: a novel mechanism of tumor development in Carney triad

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  • Society for Endocrinology Journal Award ‐ Clinical Endocrinology
  • • Drugs that interact with levothyroxine: an observational study from the Thyroid Epidemiology, Audit and Research Study (TEARS)

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  • Society for Endocrinology Journal Award ‐ Endocrine Connections
  • • Role of endogenous ACTH on circadian aldosterone rhythm in patients with primary aldosteronism

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• Symposia
• • Endocrinology meets the environment
  • • Later life consequences of maternal vitamin D deficiency - MAVIDOS study

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    • Iodine deficiency

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    • Environmental influences on autoimmunity

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  • Zoning in on adrenal tumours
  • • Somatic mutations and adrenal remodelling in hyperaldosteronism

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    • Advances in genetic causes of adrenal Cushing's

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    • The new genetics of phaeochromocytoma

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  • Fanning the flames of mitochondrial function
  • • Novel regulation of fat metabolism in cancer

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    • Abstract unavailable

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    • Mitochondrial disease: problems and solutions

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  • It's all in the timing: rhythms underlying endocrine systems
  • • Sleep: what endocrinologists should know about the body clock

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    • Rhythms of adrenal glucocorticoid secretion

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    • Dynamics in hypothalamic-pituitary function over multiple time-scales

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  • Premature ovarian insufficiency
  • • Abstract unavailable

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    • Neurological and psychological effects of premature ovarian insufficiency

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    • Abstract unavailable

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  • Clinical implications of thyroid genomics (Supported by Journal of Molecular Endocrinology)
  • • Thyroid genomics: relevance to thyroid hormone therapy

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    • Abstract unavailable

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    • TCGA genomic characterization of papillary thyroid carcinoma

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  • The rise and rise of the FGFs in endocrinology
  • • Abstract unavailable

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    • FGF21: starvation hormone to a clinical drug?

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    • The increasing understanding of FGF23 in pathogenesis and treatment of diverse endocrine disease

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  • Fine-tuning of metabolic state for optimal pregnancy outcome
  • • Revolutionising type 1 diabetes metabolic control in pregnancy

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    • Pregnancy and obesity

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    • Autoimmune thyroid disease before and during pregnancy

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  • The endocrinology of the thin (Supported by Endocrine Connections)
  • • Endocrine dysfunction in anorexia nervosa

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    • Abstract unavailable

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    • Abstract unavailable

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  • Blood and guts: how the intestine transduces nutritional cues to endocrine signals (Supported by Journal of Endocrinology)
  • • Abstract unavailable

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    • The glucoregulatory role of small intestinal nutrient- and pharmacological-sensing

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    • Short chain fatty acids in the regulation of energy homeostasis

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  • Epigenetics in endocrine-related cancers (Supported by Endocrine-Related Cancer)
  • • Oestrogen receptors and epigenetics in breast cancer aetiology and outcome

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    • Epigenetic regulation of androgen receptor function in prostate cancer

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    • Epigenetic signalling and acquired drug resistance in ovarian cancer

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  • Corticosteroids - getting to the heart of the matter (Supported by Journal of Molecular Endocrinology)
  • • Abstract unavailable

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    • Selective targeting of the mineralocorticoid receptor in cardiovascular disease

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    • Mineralocorticoid receptor antagonists: lessons from clinical trials

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• Clinical Management Workshops
• • Workshop 1: How do I do it? (Supported by Clinical Endocrinology and Endocrinology, Diabetes & Metabolism Case Reports)
  • • How do I report and interpret a dual-energy X-ray absorptiometry scan?

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    • Abstract unavailable

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    • Abstract unavailable

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    • How do I manage adrenal suppression?

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    • How do I prevent thyroid eye disease after radioiodine?

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    • How do I manage suspected non compliance for thyroxine replacement?

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  • Workshop 2: Management of pituitary disease: beyond the adenoma
  • • Abstract unavailable

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    • Abstract unavailable

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    • Abstract unavailable

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  • Workshop 3: Biological therapies - cause and cure of endocrine diseases
  • • The thyroid and rituximab

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    • Endocrine sequelae of biological therapies (Campath, other MABs, etc.)

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    • Abstract unavailable

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  • Workshop 4: How do I do it? (II) (Supported by Clinical Endocrinology and Endocrinology, Diabetes & Metabolism Case Reports)
  • • Abstract unavailable

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    • Abstract unavailable

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    • How far do I investigate chronic fatigue?

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    • How do I manage hirsutism?

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    • Managing hormone replacement therapy in the learning disabled young adult: a personal practice

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    • How do I manage men who have used anabolic steroids?

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• Applied Physiology Workshop
• • Evolving model systems for complex tissues
  • • Modelling human diseases with stem cell derived hypothalamic neurones

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    • Abstract unavailable

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    • Cell replacement and regeneration of [beta] cells as novel therapy for diabetes

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• Early Career Prize Lectures
• • (1)
  • • The physiology and pharmacology of the fasting-induced hormone, FGF21

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    • Kisspeptin- A 'key regulator' of reproductive physiology, integrating limbic circuits with the regulation of reproductive hormones

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• Meet the Expert Sessions
• • (1)
  • • Cutting edge imaging of whole endocrine organs

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    • Abstract unavailable

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    • Optimising fertility in teenage cancer survivors

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    • Investigation and management of TSHoma

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    • Abstract unavailable

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    • Frontiers in the management of hypoparathyroidism

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    • Designer receptors exclusively activated by designer drugs (DREADD) - novel pharmacological handles on the endocrine system

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    • Meet the Expert 8: updated thyroid cancer guidelines

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    • Abstract unavailable

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    • Diagnosis and management of SIADH meet the Expert 10

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• Skills
• • Skills 1: Working with the media
  • • Why should we engage with the media?

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    • Abstract unavailable

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    • Abstract unavailable

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    • Abstract unavailable

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  • Skills 2: Early Career Symposium: Effective communication: get involved, get engaged!
  • • Engaging with the public: conveying the wonders of science

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    • The battles of writing a lay summary

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    • Making science cool for kids

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    • Making your impact statement: pack a punch

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    • Making social media work for promoting and recruiting to research studies

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    • Abstract unavailable

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• Futures
• • Futures 1: Branching out with endocrinology
  • • Abstract unavailable

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    • Abstract unavailable

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    • The secret life of a core facilities manager

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  • Futures 2: Overcoming the consultancy hurdle
  • • Abstract unavailable

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    • Abstract unavailable

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    • Research pathways in endocrinology: a UK and global perspective

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  • Futures 3: Why endocrinology and diabetes?
  • • Abstract unavailable

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    • Let me tell you the way it is: from a trainee's perspective

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    • Endocrinology club in your medical school: from concept to reality, led by Cambridge example

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    • Abstract unavailable

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• Debate
• • (1)
  • • This house believe that patients with hypothyroidism should be offered combination treatment with T₃ and thyroxine if they do not respond to levothyroxine

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    • Abstract unavailable

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• Nurse Session
• • Nurse Session 1: Multiple Endocrine Neoplasia
  • • Overview of multiple endocrine neoplasia

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    • Genetics and multiple endocrine neoplasia

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    • Psychological support of the MEN patient

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  • Nurse Session 2: Nurse-led clinics
  • • Abstract unavailable

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    • Abstract unavailable

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    • Medicolegal aspects of nurse-led clinics

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• Senior Endocrinologists’ Session
• • (1)
  • • The new tachykinin, endokinin: its role in emesis, sialorrhea and smoking in pregnancy

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    • Abstract unavailable

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    • Steroid mass spectrometry: a 50 year history

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    • A crackpot ejection theory about China's unique natural glass

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    • Understanding the biochemistry underpinning hypoglycaemia of the insulin autoimmune syndrome (IAS) is paramount for diagnosis and management

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    • Abstract unavailable

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• Oral Communications
• • Early Career Oral Communications
  • • A novel pharmacological approach to target LH and testosterone hypersecretion in women with polycystic ovary syndrome: a randomised, double-blind, placebo-controlled multi-centre randomised clinical trial of the neurokinin B receptor antagonist AZD4901

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    • Mutations in IGSF10 cause self-limited delayed puberty, via disturbance of GnRH neuronal migration

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    • RNA-sequencing of mouse adrenals reveals the pathways perturbed by loss of nicotinamide nucleotide transhydrogenase

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    • Adipose tissue-specific androgen generation fuels an adverse metabolic phenotype in patients with polycystic ovary syndrome

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    • Interaction of the MR and GR in the nucleus and at DNA

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    • Urine steroid metabolomics as a diagnostic tool in primary aldosteronism

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  • Translational pathophysiology and therapeutics
  • • Dual 5-[alpha] reductase inhibition promotes hepatic lipid accumulation in man as a result of changes to lipid metabolism in adipose tissue and the liver

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    • Adrenal vein catecholamine levels and ratios: reference intervals derived from patients with primary aldosteronism

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    • Further advances in diagnosis of adrenal cancer: a high-throughput urinary steroid profiling method using liquid chromatography tandem mass spectrometry (LC-MS/MS)

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    • Development of a long-acting growth hormone antagonist for the treatment of acromegaly

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    • Age at first major osteoporotic fracture in Danes aged 50 and over: influence of diabetes on mean age at fracture and 1 year mortality

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    • Treatment with the epigenetic modifying compound JQ1+ can significantly reduce the proliferation of pancreatic neuroendocrine tumours in a mouse model of multiple endocrine neoplasia type 1

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  • Steroids and adrenal
  • • Molecular diagnosis of patients with adrenal insufficiency using a targeted custom Haloplex next-generation sequencing panel

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    • Glucocorticoids stabilise the microtubule network to inhibit cell migration

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    • 11[beta]-HSD1-mediated decrease in COX2 expression is abrogated by hypoxia in human dermal fibroblasts

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    • Urine steroid metabolomics as a novel diagnostic tool for early detection of recurrence in adrenocortical carcinoma

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    • Glucocorticoid pattern-dependent gene regulation in the rat hippocampus

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    • Female 5[beta]-reductase knockout mice are protected from diet induced obesity, insulin resistance, and glucose intolerance

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  • Diabetes and cardiometabolic complications
  • • Acute intense exercise restores defective counter-regulation in type 1 diabetes through a process of dis-habituation

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    • Thermal imaging as a novel non-invasive method to measure human brown adipose tissue activity in humans

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    • 5[alpha]-tetrahydrocorticosterone exhibits topical anti-inflammatory action with limited adverse effects on angiogenesis

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    • Hyperinsulinaemia due to inhibition of 5[alpha]-reductases is ameliorated by liver-selective glucocorticoid receptor antagonism in diet-induced obesity

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    • Glucagon increases energy expenditure independently of brown adipose tissue activation in humans

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    • Cardiac fibrosis and the balance between glucocorticoid and mineralocorticoid receptors signalling

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  • Thyroid and parathyroid
  • • Functional consequences of germline mutations in a novel non-RET medullary thyroid cancer susceptibility gene

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    • A novel, missense, mutation (P81R) in the TRH receptor gene in congenital central hypothyroidism

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    • Use of 11C-methionine PET to localise parathyroid adenoma/hyperplasia: a single centre experience

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    • A novel modulator of cellular invasion and metastasis in endocrine cancer

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    • Investigating the genetic architecture of gland-in-situ congenital hypothyroidism by comprehensive screening of eight known causative genes

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    • Safety review of liothyronine use: a 20 year observational follow up study

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  • Advances in reproduction and signalling
  • • Neurokinin B receptor antagonist limits kisspeptin-10 induced LH secretion in women

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    • Kisspeptin-54 safely and effectively triggers oocyte maturation during IVF treatment in women at high risk of developing ovarian hyperstimulation syndrome (OHSS)

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    • Mutations in HS6ST1 are causal in self-limited delayed puberty as well as idiopathic hypogonadotropic hypogonadism

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    • Calcium-sensing receptor internalisation is impaired in cells expressing FHH3-associated AP2σ mutations

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    • Pituitary tumor transforming gene binding factor (PBF): a novel modulator of iodide uptake and target for Src phosphorylation in breast cancer

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    • Glucocorticoids induce rapid and persistent chromatin remodelling at a glucocorticoid receptor bound locus in macrophages

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• Featured Posters
• • (1)
  • • Inhibition of NFAT signalling in vivo improves microvascular endothelial function in a mouse model of chronic diabetes

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    • Corticosterone in human saliva is highly abundant and lacks a diurnal rhythm

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    • Maternal genotype is an important determinant of the outcome of antenatal glucocorticoid treatment in GR+/+ and GR+/− foetal mice

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    • GLP-1 reduces cerebrospinal fluid secretion and intracranial pressure: a novel treatment for idiopathic intracranial hypertension?

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    • Generation of GnRH neurons from human embryonic stem cells and induced pluripotent stem cells of healthy individuals and patients with Kallmann's syndrome

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    • The role of 11[beta]-hydroxysteroid dehydrogenase type 2 in the central regulation of blood pressure and salt appetite

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    • Regulation of adipogenesis by wnt10b signalling in cultured human adipocytes taken from an obese patient with a WNT10B-C256Y mutation

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    • Reduced circulating levels of kisspeptin, human chorionic gonadotropin, placental-like growth factor, soluble fms-like tyrosine kinase-1 and soluble endoglin but not prokineticin-1 are associated with miscarriage risk

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    • How well can we measure oestradiol?

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    • A dedicated Turners clinic improves adherence to UK recommended best practice and is well liked by patients

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    • Potential molecular mechanism of AIP-mediated cellular invasion

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    • Characterising the functional significance of the first reported mutations in the pituitary tumor-transforming gene binding factor

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• Poster Presentations
• • Bone
  • • FHH3-associated AP2σ mutations impair MAPK signalling pathways

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    • Exploring the N-ethyl-N-nitrosourea mutagenesis DNA archive for mutations in nuclear factor I/X to derive mouse models for Marshall-Smith syndrome

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    • Reduction in daily hydrocortisone dose in adrenal insufficiency improves significantly bone mineral density - results from a 2-years prospective trial

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    • Mutations in G-protein subunit [alpha]_q (GNAQ) are not a cause of familial hypocalciuric hypercalcaemia

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    • Soy protein with isoflavones reduce bone turnover markers in women during their early menopause - a randomised double blind parallel study

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    • Increased circulating sclerostin levels in type 2 diabetic rats are not associated with changes in bone sclerostin production

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    • Differential effects of parathyroid hormone on key regulators of osteoblast mineralisation

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    • Type 2 diabetes, bone mineral density and disc height

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    • The decreased plasma levels of sclerostin but not Dickkopf-1 are associated with increased risk of osteoporotic fracture and lower bone mineral density in Korean postmenopausal women

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    • A mutation in the calcium sensing receptor (previously known to cause neonatal severe hyperparathyroidism in the homozygote state) causing familial benign hypocalciuric hypercalcaemia in the heterozygote

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    • The effect of oestradiol circadian rhythm on the bone mineral density of adult males

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    • Familial hypocalciuric hypercalcaemia due to AP2S1 mutation in a patient with failed parathyroidectomies: a case report

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    • Pre-operative localisation of parathyroid adenomas in patients with primary hyperparathyroidism: can a single modality of imaging be adequate?

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    • A rare presentation of primary hyperparathyroidism

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    • Lessons learnt after 'failed' parathyroidectomy

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    • Melorrheostosis: a rare cause of bone pain and limb deformity

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    • Denosumab improves bone density in a female patient with severe anorexia nervosa

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    • Improved glycaemia following parathyroidectomy for primary hyperparathyroidism

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  • Clinical biochemistry
  • • A comparison of plasma copeptin and AVP responses during saline infusion studies

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    • Use of ADH antagonists results in lower hospital resource usage: a retrospective cohort study

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    • Genetic hypocalcaemia: a case of 22q deletion syndrome

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    • Effect of cortisol assay bias on the overnight dexamethasone suppression test: implications for the investigation of Cushing's syndrome

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    • Using SDHB immunostaining in characterising pheochromocytoma and paraganglioma

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    • Serum cortisol: what is your laboratory measuring?

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    • Vasopressin-2 receptor antagonists: potent but potentially dangerous drugs for the treatment of severe hyponatraemia secondary to syndrome of inappropriate antidiuretic hormone secretion

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    • Lactic dehydrogenase, a biochemical marker to predict foetal outcome in pregnancies complicated by intrauterine growth restriction

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    • Turn off the taps

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    • Where are the endocrinologists?

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    • The epidemiology of hyperprolactinaemia

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    • Audit of management of patients with hypomagnesaemia in district general hospital

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    • Single-centre audit of the diagnostic performance of plasma metanephrines with seated sampling for the diagnosis of phaeochromocytoma/paraganglioma

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    • An unusual presentation of osmotic demyelination syndrome

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    • Management of inpatient hypokalaemia: a District General Hospital (DGH) experience

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    • Alkaline phosphatase may predict tumour volume in patients with parathyroid adenoma

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    • Biochemical evaluation of adrenal incidentalomas referred to endocrine surgery in a large teaching hospital

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    • Inhibiting more than the proton pump

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    • Asymptomatic hypokalaemia in an identical twin

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    • Severe hyponatraemia in an inpatient setting - a role for the Endocrinologist?

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    • Are we doing to many short synecthan test

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    • A case of B cell lymphoma of brain presenting as syndrome of inappropriate antidiuretic hormone secretion

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    • Audit of the diagnosis and management of primary hyperparathyroidism

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    • Novel treatment of refractory hypercalcaemia: a serendipitous discovery

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  • Clinical practice/governance and case reports
  • • What is the prevalence of severe post-operative hypocalcaemia in patients who have undergone parathyroid surgery or a total thyroidectomy at the RVI, Newcastle? Does vitamin D play a role?

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    • Urgent requirement for better patient selection for short Synacthen tests: results from a clinical audit

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    • Using Skype follow-up consultations for patients with thyroid disease

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    • Review in specialist Turner clinic improves management

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    • A rare incidental cause of Cushing's syndrome

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    • Partial response to sunitinib therapy in a metastatic dopamine-secreting paraganglioma

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    • Outcome of patients with adrenal incidentalomas: an analysis of 145 patients from a single centre

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    • Early post-operative aldosterone concentration can be used to assess outcome from adrenalectomy in aldosterone producing adenoma

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    • Saccular internal carotid artery aneurysm masquerading as pituitary macroadenoma

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    • Impact of a multidisciplinary diabetic foot clinic on patient outcomes

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    • Out-of-hours cover for diabetes and endocrinology: a single UK tertiary centre experience

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    • TB or not TB: that is the question

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    • A case of polyglandular autoimmune disease associated with common variable immunodeficiency

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    • Phaeochromocytoma in pregnancy: good luck and judgement lead to a successful outcome

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    • Audit on continuous subcutaneous insulin infusion (insulin pump) therapy

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    • Vitamin D deficiency in haemodialysis patients; treatment with colecalciferol

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    • DIPNECH: under-recognised and a diagnostic challenge

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    • Sodium-glucose co-transporter 2 inhibitor associated normoglycaemic ketoacidosis

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    • A novel management of Gitelman's syndrome

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    • Nothing to 'sea' here: turning a blind eye to hyponatraemia

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    • A case to remember

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    • Resistant hypocalcaemia secondary to denosumab: two case reports

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    • Multiple endocrine paraneoplastic syndromes in a patient with lung malignancy

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    • National Audit of Transition in Endocrinology: joint between Society for Endocrinology and the British Society of Paediatric Endocrinology and Diabetes

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    • IgG4-related hypophysitis: a novel candidate to the hypophysitis spectrum

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    • Management of thyroid disease in pregnancy: experience from an antenatal thyroid clinic

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    • Endometrial hyperplasia in transmen: to scan or not to scan?

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    • Steroid responsive hypoglycaemia in a patient with spindle cell sarcoma

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    • Does the usual time of rising influence the stimulated cortisol response?

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    • A woman with thyroid metastases 21 years after renal carcinoma excision, with biphasic thyroid dysfunction on sunitinib

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    • Immobilisation hypercalcaemia in two intensive care patients

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    • Audit on hyponatraemia in a West Kent Hospital experience

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    • Large benign nerve sheath tumour in the adrenal gland: an incidental finding

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    • Aromatase inhibitor: potential therapy for obesity related hypogonadotropic hypogonadism and gynaecomastia

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    • Phaeochromocytoma: experience from a single centre in South India

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    • Pituicytoma, not a 'meningioma': late recurrence in a rare pituitary tumour

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    • Somatotroph adenoma localised with composite 11C-methionine PET/MRI: a cost effective solution

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    • Vitamin D resistant idiopathic hypoparathyroidism

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    • Glycogenic hepatopathy: a tale infrequently told in the diabetes world

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    • Should all short Synacthen tests be agreed by an endocrine team?

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    • Artifactual hypoglycaemia: lesson from a patient with unreliable finger-prick glucose due to absent finger tips

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    • Decreased conscious level and a renal mass

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    • An index case of MEN1 identified with imaging of the right thigh

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    • Four years of tolvaptan: experience from two large teaching hospitals

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    • A single-centre experience of adrenal vein sampling in a District General Hospital serving a remote and rural population

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    • Haemofiltration as a treatment option in refractory life-threatening diabetic ketoacidosis

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    • Adrenal insufficiency caused by bilateral primary adrenal lymphoma

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    • Congenital adrenal hyperplasia: are we really lost in transition?

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    • Audit of Plenadren use in selected patients

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    • Clinical practice, governance, and case reports: hypovitaminosis D as a cause of severe hypocalcaemia in a Nigerian female

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    • Evaluation of use of combination dapagliflozin and GLP1 agonist treatment in type 2 diabetes

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    • Do guidelines improve the diagnosis and investigation of hyponatraemia?

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    • Diaphoresis: an unusual initial presenting complaint of Cushing's syndrome

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    • An unusual case of 'adrenal' Cushing's

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    • Accuracy of sample timing with short Synacthen tests at Royal Bournemouth Hospital

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    • Hyponatremia: an audit of the initial investigation and management

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    • A case of haemorrhagic adrenalitis due to streptococcus oralis

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    • Xerostomia: an unseen consequence of statin use

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    • A complex case of MEN1

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    • Hyperalphalipoproteinaemia in epileptic patient: cardiovascular protection from carbamaezipine use?

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    • Splenunculi masquerading as neuroendocrine tumours

      ea0038p103
    • UK primary hyperparathyroidism clinical practice audit

      ea0038p104
    • Pregnancy and lactation-associated osteoporosis: two case reports

      ea0038p105
    • Pseudohypoparathyroidism: a case of delayed diagnosis

      ea0038p106
    • Opiate induced multiple pituitary hormone deficits

      ea0038p107
    • Separate, sequential, endocrine, and glycaemic effects of ipilimumab and pembrolizumab in metastatic melanoma

      ea0038p108
    • Resistant hyperparathyroidism and hepatitis: is there a link?

      ea0038p109
    • Hypogonadism in Noonan syndrome

      ea0038p110
    • Hungry bones: a case of severe complications post parathyroidectomy

      ea0038p111
    • Carbarmazepine and Cushing's: a cautionary tale of assay interference mimicking disease

      ea0038p112
    • Foreign bariatric procedures: help or hindrance for the NHS?

      ea0038p113
    • Variation in levels of macroprolactin in the investigation of secondary hypogonadism

      ea0038p114
    • Audit of adult GH replacement therapy in Nottingham

      ea0038p115
    • Erectile dysfunction, diabetes mellitus, and sun-tan: the hypogonadism story with a difference

      ea0038p116
    • Cardiac manifestations of a phaeochromocytoma

      ea0038p117
    • Management of patients with adrenal insufficiency attending Galway University Hospital compared with current best practice

      ea0038p118
    • An audit in to the investigation of spontaneous hypoglycaemia: experience at a tertiary centre

      ea0038p119
    • Cyclophosphamide induced seminiferous tubule damage causing raised FSH and LH, and high testosterone levels

      ea0038p120
    • A case of morning headache: Doege-Potter syndrome

      ea0038p121
    • The effects of maggot debridement therapy on length of hospital inpatient stay

      ea0038p122
    • A case of adrenal haemorrhage in severe sepsis

      ea0038p123
    • A case of Graves' disease occurring following cessation of the oral combined contraceptive pill

      ea0038p124
    • Benign or malignant adreno-cortical tumour; the relevance of size and androgen secretory capacity

      ea0038p125
    • Three cases highlighting the varied clinical presentations of adrenal haemorrhages

      ea0038p126
    • Asymptomatic Paget's disease of the bone in a 62-year-old Nigerian man: 3 years post alendronate therapy

      ea0038p127
    • Does thyroid armour cause autoimmune thyroid disease?

      ea0038p128
  • Cytokines and growth factors
  • • Expression of cytokines in placenta from pregnancies complicated by intrauterine growth restriction with abnormal umbilical artery Doppler indices

      ea0038p129
    • Interleukin 27: a predictive marker for diabetic retinopathy progression

      ea0038p130
  • Growth and development
  • • Hormonal control of [beta]-cell proliferation in fetal ovine pancreatic islets in vitro

      ea0038p140
    • Inter-correlations between placental genes regulating foetal glucocorticoid exposure and IGF2 in maternal severe obesity: a mechanism for higher birthweight?

      ea0038p141
    • Human foetal adrenal gland development and effects of maternal smoking

      ea0038p142
    • Vitamin D promotes myogenic differentiation and induces an antifibrotic phenotype in primary cultures of skeletal muscle derived satellite cells and fibroblasts

      ea0038p143
    • Hypothyroidism, altered leptin and c-reactive protein synthesis characterised pregnancy exposed to genistein

      ea0038p144
  • Neoplasia, cancer and late effects
  • • Nicotinamide nucleotide transhydrogenase (NNT) as a novel molecular target in adrenocortical carcinoma - impact of NNT knockdown on adrenocortical cell proliferation, redox balance and steroidogenesis

      ea0038p145
    • The somatostatin analogue pasireotide decreased proliferation and increased apoptosis in pancreatic and pituitary neuroendocrine tumors in a MEN1 mouse model

      ea0038p146
    • Steroid sulphatase and G-protein coupled oestrogen receptor in human colorectal cancer: correlation with late-stage disease and potential therapeutic targets

      ea0038p147
    • PTTG is phosphorylated at residue T60 and regulates p53 stability, in conjunction with PBF, in head and neck cancer

      ea0038p148
    • Distinct p53 response profiles in transgenic mouse models of thyroid-specific PBF and PTTG expression

      ea0038p149
    • Follow up of differentiated thyroid cancer survivors during pregnancy: a retrospective analysis

      ea0038p150
    • Pituitary-related outcomes of cranial radiotherapy (cXRT) in adults with gliomas

      ea0038p151
    • Phenotypic heterogeneity associated with proglucagon-expressing tumours is due to differential processing and secretion of proglucagon-derived peptides

      ea0038p152
    • Novel targeted treatment combinations for malignant neuroendocrine tumour olfactory neuroblastoma

      ea0038p153
    • Adrenal pigmentation in PPNAD is a result of melanin deposition and associated with upregulation of the melanocortin 1 receptor

      ea0038p154
    • Primary cilia: a new player in phaeochromocytoma pathogenesis?

      ea0038p155
    • Adverse metabolic profile in long-term survivors of adult and childhood-onset brain tumours: the role of growth hormone deficiency

      ea0038p156
    • Ultrasound-guided percutaneous ethanol ablation for selected patients with papillary thyroid microcarcinoma: a novel, effective and well tolerated alternative to neck surgery or observation

      ea0038p157
    • Clot structure analysis in survivors of acute lymphoblastic leukaemia: the role of growth hormone deficiency

      ea0038p158
    • Use of Sunitinib in refractory hypercalcaemia in pancreatic neuroendocrine tumours

      ea0038p159
    • Chromogranin B: a possible prognostic biomarker for neuroendocrine tumours?

      ea0038p160
    • Imaging and evaluating side effects of antiandrogen therapy

      ea0038p161
    • Outcome of insulinomas diagnosed in a tertiary endocrine centre

      ea0038p162
    • Metastatic paraganglioma with isolated 3-methoxytyramine rise in a patient with SDHC mutation

      ea0038p163
    • Recurrent phaeochromocytomas in type2C variant of Von Hippel-Lindau syndrome

      ea0038p164
    • Lutetium ablation therapy as treatment for recurrent metastatic bladder paraganglioma

      ea0038p165
    • Somatostatin responsive ACTH and precursor excess in a midgut mesentery NET

      ea0038p166
    • Primary adrenal lymphoma

      ea0038p167
    • Metastatic bowel carcinoid associated bilateral carcinoid heart disease

      ea0038p168
    • Familial insulinoma in the absence of MEN

      ea0038p169
    • A young girl with bilateral adrenal tumours

      ea0038p170
    • Acromegaly in association with a bronchial carcinoid tumour

      ea0038p171
    • Challenges in the diagnosis and management of a case of glucagonoma first presenting as a localised genital rash

      ea0038p172
    • A management dilemma - emergency treatment of primary hyperparathyroidism in suspected but unconfirmed multiple endocrine neoplasia type 1

      ea0038p173
    • Promoter methylation signatures of BRCA2 and TP53 genes in the serum of some breast cancer patients attending radiotherapy clinic in Lagos, Nigeria

      ea0038p174
    • Confusion in a patient with carcinoid syndrome

      ea0038p175
  • Nursing practise
  • • Utilisation of nurse led clinics in endocrinology practice

      ea0038p176
    • How is the Society for Endocrinology Competency Framework for Adult Endocrine Nursing used in practice?

      ea0038p177
    • Pre-pituitary surgery patient satisfaction audit 2015

      ea0038p178
    • Development of IT based nurse led endocrine tracking system

      ea0038p179
    • A care service model for cost effective and structured individualised treatment choice for GH replacement therapy

      ea0038p180
    • Recurring abscesses at injection sites on the home injection programme

      ea0038p181
  • Obesity, diabetes, metabolism and cardiovascular
  • • Testing causality in the association of plasma cortisol with risk of coronary heart disease: a Mendelian randomisation study

      ea0038p182
    • Gender-related differences in circulating microparticles characteristics: implications for cardiovascular risk?

      ea0038p183
    • Longer duration of sitting down in pregnancy is associated with gestational diabetes, greater weight gain and depressive symptoms

      ea0038p184
    • Transcriptome profiles of human pancreatic islets following transient ischemia identify inflammatory and cell death responses

      ea0038p185
    • Studies of Nuf mice with an activating calcium-sensing receptor (CaSR) mutation demonstrate the CaSR to regulate pancreatic beta-cell mass and glucose homeostasis

      ea0038p186
    • Role of oral cholecalciferol as adjuvant therapy in type 1 diabetes mellitus: randomised controlled trial

      ea0038p187
    • Prevalence and determinants of metabolic syndrome among HIV infected patients receiving highly active antiretroviral therapy in Kano, northwestern Nigeria

      ea0038p188
    • The effect of L-arginine on anorectic gut hormone release in humans

      ea0038p189
    • Generation of a long acting GCSF for treatment of neutropenia and stem cell harvest

      ea0038p190
    • Hypercortisolaemia increases femoral adipose tissue blood flow but not net fatty acid release in vivo

      ea0038p191
    • Central IL6 signalling and the development of impaired insulin secretion in type2 diabetes

      ea0038p192
    • Women with idiopathic intracranial hypertension have a distinct andro-metabolic signature compared to polycystic ovary syndrome and simple obesity

      ea0038p193
    • Differences between men and women in markers of dietary fatty acid oxidation

      ea0038p194
    • Establishing human liver cell models to investigate the effects of exogenous metabolic substrates on fatty acid partitioning

      ea0038p195
    • Evidence for 11[beta]-HSD1 regulation of brain energy metabolism following systemic inflammation

      ea0038p196
    • Impact of number of transplanted human islet equivalents on successful return to normoglycaemia in an NSG diabetic mouse model

      ea0038p197
    • Vascular dysfunction in horses with insulin resistance

      ea0038p198
    • Evidence for improved mitochondrial efficiency in adipose tissue of T2DM women after malabsorptive but not restrictive bariatric surgery

      ea0038p199
    • AMPK activators modulate pro-inflammatory responses in human adipocytes

      ea0038p200
    • eNAMPT-monomer plays a critical role in pathophysiology of experimental diabetes and represents a novel target for treatment of type 2 diabetes

      ea0038p201
    • Predictors of glycaemic response and impact on weight and BP of dapagliflozin therapy in type 2 diabetes

      ea0038p202
    • Pre-operative assessment for Sleep apnoea in patients referred for bariatric surgery: the usefulness of various clinical screening tools

      ea0038p203
    • Effect of vitamin D supplementation on cardiovascular risk factors and exercise performance in healthy subjects; a randomised placebo controlled pilot study

      ea0038p204
    • Evaluation of adipocytokines and traditional cardiometabolic risk factors in young male cancer survivors: an age-matched control study

      ea0038p205
    • Low vitamin B12 in pregnancy is associated with maternal obesity and gestational diabetes

      ea0038p206
    • Adrenaline mediated metabolic and functional quiescence protects insulin producing cells from hypoxia

      ea0038p207
    • Bile acids stimulate GLP-1 release predominantly by accessing basolateral GPBAR1 (TGR5)

      ea0038p208
    • Vitamin B12 deficiency alters adipogenesis and associated microRNA's in human adipocytes

      ea0038p209
    • Proteomic detection of extracellular matrix proteins in insulin-resistant skeletal muscle

      ea0038p210
    • Longitudinal changes in adipose tissue gene expression profile are asociated with deteriorating glucose tolerance

      ea0038p211
    • Distinguishing different subtypes of aldosterone-producing adenoma by histological, immunohistochemical and radiological features; a basis for individualised treatment strategies in primary aldosteronism?

      ea0038p212
    • Adrenal insufficiency following bariatric surgery

      ea0038p213
    • Discovery and localisation of the expression of calcitonin-type and CRH-type neuropeptide precursors in an echinoderm

      ea0038p214
    • The role of vitamin B12 deficiency in molecular mechanism of metformin

      ea0038p215
    • Enhanced orbitofrontal cortex activation following sympathetic neural stimulation in young women with polycystic ovary syndrome: an fMRI study

      ea0038p216
    • Enhanced insulin secretion and insulin action in young lambs with intrauterine growth restriction

      ea0038p217
    • Glucocorticoid excess increases hypothalamic AgRP and results in obesity and hyperinsulinaemia in mice

      ea0038p218
    • Non-selective beta-adrenergic agonist infusion acutely stimulates the temperature of brown adipose tissue in adult males

      ea0038p219
    • Endogenous ARX knockdown enhances beta-cell lineage specification and maturation during ex vivo transdifferentiation of human exocrine pancreatic tissue

      ea0038p220
    • Altered adipocytes in an ovine model of polycystic ovary syndrome

      ea0038p221
    • Transcriptional profiles explain insulin hypersecretion following chronic adrenergic stimulation in foetal sheep islets

      ea0038p222
    • Measuring the contribution of de novo lipogenesis to fatty liver disease: a mouse and translational human study using high resolution mass spectrometry

      ea0038p223
    • The hypoglycaemic and antioxidant properties of oleanolic acid ameliorate blood pressure and kidney function of experimental animals

      ea0038p224
    • Dietary cocoa (Theobroma cacao) and turmeric (Curcuma longa) consumption: a comparison of metabolic effect in high-fat fed rats

      ea0038p225
    • Glucose tolerance, insulin sensitivity and adiponectin level in niacin-treated obese rats

      ea0038p226
    • Circadian rhythm of ambulatory blood pressure in rotating night shift nursing professionals and its relation with 6- sulfatoxy melatonin as neuroendocrine chronomolecule

      ea0038p227
    • Characterising fat distribution and response to weight loss in idiopathic intracranial hypertension

      ea0038p228
    • Anti-inflammatory effects of metformin and their relationship to the therapeutic action of the drug

      ea0038p229
    • Maternal overnutrition programs hypothalamic neuropeptides and metabolic syndrome in offspring

      ea0038p230
    • 'Thin-fat' phenotype in early foetal life in GDM pregnancies - novel evidence from an Indian Cohort

      ea0038p231
    • Functional significance of renal gene expression changes in a mouse model of ACTH-dependent Cushing's syndrome

      ea0038p232
    • Brown adipose tissue plays a role in regulating fetal growth by undergoing a gestational-dependent phenotypic change

      ea0038p233
    • Seasonal variation of HbA_1c

      ea0038p234
    • Relationship between high-sensitivity C-reactive protein and anthropometric indices of obesity

      ea0038p235
    • 2[beta]-hydroxybetulinic acid 3[beta]-caprylate: an active principle from euryale ferox salisb. seeds with antidiabetic, antioxidant, pancreas & hepatoprotective potential in streptozotocin induced diabetic rats

      ea0038p236
    • Clinical profile and outcome of patients with hyperglycaemic emergencies presenting at a rural hospital in southern Nigeria

      ea0038p237
    • Diabetic neuropathy: an evaluation using the ntss-6 questionnaire and biothesiometry in type 2 DM patients

      ea0038p238
    • Hypothalamic glucocorticoid levels increase in an in vivo model of glucocorticoid-induced obesity and hyperinsulinaemia

      ea0038p239
    • Effects of androgen on the adipokinome and metabolic genes in white and brown adipose tissue

      ea0038p240
    • From the bronze age to the iron age

      ea0038p241
    • Characterisation of the astrocytic response to acute and recurrent hypoglycaemia

      ea0038p242
    • Markers of adipose tissue hypoxia are elevated in subcutaneous adipose tissue of morbidly obese patients with hypoventilation syndrome and obstructive sleep apnoea syndrome but not in the moderately obese

      ea0038p243
    • Prevalence of diabetes mellitus among HIV patients in Kano, northwestern Nigeria

      ea0038p244
    • Obstructive sleep apnoea and bariatric surgery: the need for more universal screening and post-operative follow up

      ea0038p245
    • The effect of soy protein with and without isoflavones in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised double-blind parallel study

      ea0038p246
    • Is polycythaemia a marker of an increased cardiovascular risk in transmen?

      ea0038p247
    • Cost of illness among patients with diabetic foot ulcer in secondary and tertiary health facilities in Kano, northwestern Nigeria

      ea0038p248
    • Impact of DAFNE and subsequent CSII therapy on glycaemic control in type 1 diabetes mellitus

      ea0038p249
    • Lifelong exposure to sewage sludge chemicals causes proteome-wide and sex-specific disturbances in the liver

      ea0038p250
    • GLP1 agonist based therapy has modest effect on weight and glycaemic control among UAE patients with diabetes: analysis of data on 3725 patients

      ea0038p260
    • Extracts of Hymenocardia acida ameliorate insulin resistance in skeletal muscle cells

      ea0038p261
    • A study of metabolic syndrome among HAART naive HIV patients in Kano, northwestern Nigeria

      ea0038p262
    • Anthropometric indices: optimal cut-off values for abdominal obesity in adult Nigerians

      ea0038p263
    • Influence of gender on the distribution of type 2 diabetic complications at the Obafemi Awolowo Teaching Hospital, Ile-Ife, Nigeria

      ea0038p264
    • A study of the influence of West African ethnicity and gender on [beta]-cell function and insulin sensitivity in essential hypertensives treated with hydrochlorothiazide and hydrochlorothiazide-lisinopril combination

      ea0038p265
    • Comparison of surrogate measures of percentage body fat with bioelectric impedance in Nigerians

      ea0038p266
    • Evidence of foetal growth restriction in South-Asian foetuses of GDM mothers?

      ea0038p267
    • Prediabetes incidence and risk of developing cardiovascular disease in women with polycystic ovary syndrome

      ea0038p268
    • Improving glycaemic control in T1DM: the Fife Insulin and Food Education for Diabetes (FIFE Diabetes) structured education programme

      ea0038p269
    • Intra-Individual correlation between flow mediated dilation and reactive hyperaemia peripheral arterial tonometry in PCOS

      ea0038p270
    • Evaluation of hypoglycaemia unawareness in individuals with type 1 diabetes mellitus using continuous glucose monitoring in a tertiary care centre

      ea0038p271
    • Postnatal screening in patients with gestational diabetes

      ea0038p272
    • Prevalence of vitamin D deficiency and its association with diabetes in a South-Asian population

      ea0038p273
    • What the mouth has to say about diabetes in a Nigerian Tertiary Hospital

      ea0038p274
    • Anthropometric indexes correlate of body fat percentage among Nigerians

      ea0038p275
    • Lipid profile in apparently healthy Nigerian adults

      ea0038p276
    • Overweight and obesity in a rural Nigerian adult population

      ea0038p277
    • Comparison of glycaemic control in patients with type-1 diabetes mellitus on CSII therapy with different basal rates

      ea0038p278
    • Effects of gypenoside on pancreatic beta cell function and insulin secretion

      ea0038p279
    • GPR142 plays a critical role in Tryptophan-induced insulin and incretin secretion in mice

      ea0038p280
    • Inborn errors of metabolism and the endocrinologist

      ea0038p281
    • An unusual case of fish odour syndrome - tabloid paper helped in diagnosis?

      ea0038p282
    • eGFR using CKD- EPI, MDRD and COCKCROFT - GAULT and glycaemic control among type 2 diabetics in an out-patient clinic in Nigeria

      ea0038p283
    • Correlates of dysglycaemia and implications for diabetes care in Calabar, Nigeria

      ea0038p284
    • Prevalence and risk factors for obesity among HIV patients in Kano, north western Nigeria

      ea0038p285
    • Relationship between three indices of central obesity and fasting plasma glucose

      ea0038p286
    • How well do front line healthcare professionals understand type 2 diabetes?

      ea0038p287
    • Accuracy and reliability of glucose meters used at diabetes clinic of Oauthc Ile Ife

      ea0038p288
    • Behavioural risk factors for diabetes mellitus: a study of secondary school staff in a community in south west Nigeria

      ea0038p289
    • Influence of deuterium depleted water on indicators of prooxidant-antioxidant and detoxifying systems in experimental diabetes

      ea0038p290
    • Renal function in type 2 diabetes patients at presentation in a tertiary hospital in Nigeria - a preliminary report

      ea0038p291
    • Bloods glucose monitoring in diabetic inpatients - hyperglycaemia

      ea0038p292
    • Case report of a type 2 DM patient with vitamin B12 deficiency anaemia

      ea0038p293
    • Relationship between anthropometric indices and insulin resistance in Nigerians with type 2 diabetes mellitus

      ea0038p294
    • Assessment of the relationship between obesity indices and lipid parameters among Nigerians with hypertension

      ea0038p295
    • Hyperuricaemia and peripheral arterial disease in patients with diabetes mellitus

      ea0038p296
    • Similia similibus curantur: using DPP-IV inhibitor to treat reactive hypoglycaemia

      ea0038p297
    • Clinical profile of persons with diabetes attending an endocrinology clinic in a tertiary hospital in rural Nigeria

      ea0038p298
  • Pituitary
  • • A role for ¹¹C-methionine PET/CT-MRI in the management of de novo and residual acromegaly

      ea0038p299
    • The effect of AIP on AHR transcriptional activity: implications for AIP mutations pathogenicity

      ea0038p300
    • Investigation of the invasive phenotype of AIP-mutated pituitary adenomas

      ea0038p301
    • Menin regulates the expression of miR-15a, which is downregulated and inversely correlates with cyclin D1 expression in mouse Men1-associated pituitary tumours

      ea0038p302
    • An association between visual morphometric changes and psychiatric outcomes in patients with acromegaly

      ea0038p303
    • The founder R304* AIP mutation is prevalent in Irish acromegaly and gigantism patients as well as in the general population of Ireland

      ea0038p304
    • In vitro effects of Imatinib on somatotrophinoma cell line

      ea0038p305
    • Unique clinical picture in patients with X-linked acrogigantism

      ea0038p306
    • Silencing of aryl hydrocarbon receptor protein (AIP) up-regulates the small Rho GTPase, CDC42

      ea0038p307
    • Antisense oligomer therapy directed at the GH receptor is associated with reduction in circulating GHBP levels

      ea0038p308
    • Developing a pituitary distress thermometer (PDT) - a means to improve patient quality of life

      ea0038p309
    • Mortality of patients with non-functioning pituitary macroadenoma is significantly elevated: systematic analysis of 546 cases in a tertiary referral centre in the UK

      ea0038p310
    • The burden of AIP mutations in pituitary adenoma patients from the UK

      ea0038p311
    • ACTH and gonadotrophin deficiency predict mortality in patients treated for non-functioning pituitary adenomas (NFPAs) in the UK and Republic of Ireland: long-term follow-up of 519 patients across two tertiary referral centres

      ea0038p312
    • A prospective observational study of the causation and management of SIADH in a tertiary referral hospital

      ea0038p313
    • Biochemical assessment of disease activity in acromegaly; a comparison of single GH, GH day series mean, OGTT nadir and IGF-1 in 51 patients

      ea0038p314
    • Expression of MGMT in a large series of pituitary adenomas: lactotroph and corticotroph adenomas are more likely to be MGMT-negative than somatotroph and gonadotroph adenomas

      ea0038p315
    • Does basal post-operative early morning cortisol measurement predict HPA axis integrity as assessed by an insulin tolerance test in patients who have undergone pituitary surgery?

      ea0038p316
    • Patient experiences of living with acromegaly in the UK

      ea0038p317
    • An association between self-drawing, morphometric changes and psychological outcomes in patients with acromegaly vs non-functioning pituitary adenoma

      ea0038p318
    • The accuracy of bilateral inferior petrosal sinus cannulation and usefulness of prolactin adjustment in one Scottish centre

      ea0038p319
    • Neuronatin emerges in the rat pituitary stem/progenitor cells and terminates its role in the terminally differentiating cells

      ea0038p320
    • Current clinical management of acromegaly in the UK; a survey of endocrinologists

      ea0038p321
    • Traditional cardiac risk factors in a cohort of hypopituitary patients: a preliminary look at the utility of QRISK2 score

      ea0038p322
    • Long term follow up of patients with craniopharyngioma

      ea0038p323
    • Metabolic state in ACTH insufficient and ACTH sufficient patients with hypopituitarism not treated for growth hormone deficiency (GHD): a comparative study

      ea0038p324
    • Using modified clamp study to replicate insulin stress test

      ea0038p325
    • Impaired quality of life in patients with acromegaly despite long-term disease control: results from a longitudinal study

      ea0038p326
    • Pituitary incidentaloma: features and outcomes: recent experience at a tertiary centre

      ea0038p327
    • Development of a patient-reported outcome measure for pituitary surgery

      ea0038p328
    • Management of pituitary apoplexy: the greater Manchester experience

      ea0038p329
    • Feedback and GnRH pulse frequency decoding: a mathematical model for GnRH signalling in gonadotrophs

      ea0038p330
    • Keep calm and give cabergoline: a giant prolactinoma presenting with seizures

      ea0038p331
    • Loperamide-induced hypopituitarism

      ea0038p332
    • An unusual case of pituitary pathology and the utility of whole body 18F-FDG PET-CT imaging in identifying extraneural biopsy targets

      ea0038p333
    • Clinically non-functioning pituitary macroadenomas: presenting features and outcomes: recent experience at a tertiary centre

      ea0038p334
    • Pituitary service review in a District General Hospital: a case for nationally agreed guidelines?

      ea0038p335
    • A case of pituitary functional recovery in a patient with Langerhan's cell histiocytosis following chemotherapy with chlorodeoxyadenosine and mercaptopurine

      ea0038p336
    • Unusual features in a case of hypophysitis following ipilimumab therapy

      ea0038p337
    • Evolution in acromegalic patients with discordant GH-IGF1 levels during medical treatment

      ea0038p338
    • Frontal bone recurrent ectopic craniopharyngioma after transfrontal resection: case report

      ea0038p339
    • An unusual case of acromegaly

      ea0038p340
    • How common is ipilimumab-induced hypophysitis leading to cortisol deficiency?

      ea0038p341
    • TSH-secreting pituitary adenoma with negative TSH staining

      ea0038p342
    • An unusual cause of headache in pregnancy

      ea0038p343
    • The aggressive clinical course of silent corticotroph pituitary adenomas: a case series

      ea0038p344
    • Intrasellar meningioma

      ea0038p345
    • Silent corticotroph adenoma presenting with severe visual loss

      ea0038p346
  • Reproduction
  • • Analysis of the human foetal gonadal proteome at 13-14 weeks of gestation

      ea0038p347
    • Development of a single-injection non-surgical sterilant via modification of measles virus pseudotyped particles

      ea0038p348
    • Decoding gonadotrophin receptor signalling via spatial regulation of the LH receptor

      ea0038p349
    • IGF1 action in trophoblast involves endocytic and post-endocytic pathways

      ea0038p350
    • Intracrine androgens enhance decidualisation and modulate expression of human endometrial receptivity genes

      ea0038p351
    • I.v. and s.c. infusions of kisspeptin-54 stimulate gonadotrophin release similarly in healthy women

      ea0038p352
    • Assessment of reproductive parameters and oxidative stress following treatment with alcohol and/or cannabinol in male Wistar rats

      ea0038p353
    • Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis

      ea0038p354
    • Vitamin D regulates extravillous trophoblast migration by inhibiting sphingosine-1-phosphate (S1P) signalling via S1P receptor 2

      ea0038p355
    • Visceral fat drives 5[alpha]-reductase activity independent of BMI in women with polycystic ovarian syndrome

      ea0038p356
    • Impact of male cholestasis on the sperm epigenome and consequences for the health of the offspring

      ea0038p357
    • Isoform-specific knockdown of PKC isoforms reveals PKC[beta]2 is required for epidermal growth factor stimulated expression of the prostaglandin synthase COX2 in human myometrium

      ea0038p358
    • Information transfer in GnRH signalling: ERK-mediated feedback loops control hormone sensing

      ea0038p359
    • Whole exome sequencing in congenital hypogonadotropic hypogonadism

      ea0038p360
    • Implantation and pregnancy outcome of rats fed with low and high salt diet

      ea0038p361
    • Vitamin D metabolic profiling across pregnancy

      ea0038p362
    • Vitamin D and foetomaternal immunity: effects on uterine natural killer cells

      ea0038p363
    • Use of an animal model to identify the origin and validity of the testicular dysgenesis syndrome hypothesis in humans

      ea0038p364
    • Investigation into the effects of glucocorticoids in a mouse model of induced menstruation

      ea0038p365
    • Structured education programme to improve cardiovascular risk in women with polycystic ovary syndrome: SUCCESS-RCT improved physical activity and illness perception

      ea0038p366
    • Characterisation of a GnRH-type signalling system in an echinoderm

      ea0038p367
    • Low-dose gonadotrophin therapy for induction of ovulation: comparison of results in women with PCOS or hypothalamic amenorrhoea

      ea0038p368
    • Characterisation of bile acid pathways in steroidogenic tissues

      ea0038p369
    • Food, drink and medical plants and their molecules can affect female hormones and reproductive functions

      ea0038p370
    • Regulation of Cyp17a1 expression in mouse ovarian theca cells in vivo and in vitro

      ea0038p371
    • Maternal insulin-like growth factor-1 and transforming growth factor beta-1 levels during pregnancy in rats fed with low and high salt

      ea0038p372
    • Identification of novel transcription factors that may regulate transcription of the equine chorionic gonadotrophin beta subunit

      ea0038p373
    • A rare form genetic abnormality in Turner syndrome

      ea0038p374
    • Long-term monitoring of hypogonadal men receiving intramuscular testosterone replacement: a retrospective audit

      ea0038p375
    • Prevalence and correlates of premature ejaculation among Nigerians in a tertiary health centre: a preliminary cross-sectional study

      ea0038p376
    • Effects of oral, injectable, and implant hormonal contraception on serum levels of iron, ferritin, copper, ceruloplasmin and vitamin E

      ea0038p377
    • Importance of social support and implications of gender reassignment in congenital adrenal hyperplasia due to 3-[beta] hydroxysteroid deficiency

      ea0038p378
    • Testicular regression syndrome and severe psychiatric disorder - a rare association preventing the optimal management of the endocrine condition

      ea0038p379
    • Self medication in transpeople is not associated with deterioration in cardiovascular risk factors but is associated with reduced vitamin D levels and antidepressant use

      ea0038p380
    • A pragmatic review of patient satisfaction and testosterone replacement therapy

      ea0038p381
    • Spontaneous resolution of hypothalamic amenorrhea post diagnostic GnRH test

      ea0038p382
  • Steroids
  • • Adrenocortical function in glucocorticoid receptor deficient mice

      ea0038p383
    • TNF[alpha] regulates steroid sulphatase activity in healthy and malignant tissue

      ea0038p384
    • Genome-wide binding analysis of glucocorticoid receptors in the rat hippocampus in response to corticosterone and stress

      ea0038p385
    • Impact of 5[alpha]-dihydrotestosterone (DHT) on glandular epithelial proliferation in the mouse uterus

      ea0038p386
    • Plasma corticosteroid-binding globulin: biomarker of inflammation onset and severity in a rat arthritis model

      ea0038p387
    • A novel animal model to explore the whole-organism response to 21-hydroxylase deficiency

      ea0038p388
    • Regulation of glucocorticoid receptor action by ARID subunits of the SWI/SNF complex

      ea0038p389
    • Alpha-MSH secretion from a gastro-intestinal stromal tumour leading to ACTH-independent Cushing's syndrome

      ea0038p390
    • Involvement of the TORC isoforms in adrenal responsiveness to basal and stress-induced HPA activity

      ea0038p391
    • Exploring metabolomic changes due to cortisol deficiency in early development using the ferredoxin (fdx1b) null-allele zebrafish

      ea0038p392
    • The effects of chronic administration of the synthetic glucocorticoid dexamethasone on memory and learning in the rat

      ea0038p393
    • Synthetic glucocorticoid (GC) treatment induces prolonged activation of GC receptors in discrete brain regions and impairs memory and learning processes in the rat

      ea0038p394
    • Vitamin D2 vs vitamin D3: effects of total and free 25-hydroxyvitamin D on immune cells in vivo

      ea0038p395
    • Model systems to define the role of AKR1D1 in metabolic liver disease

      ea0038p396
    • Molecular and immunohistochemical analysis of aldosterone producing adenomas

      ea0038p397
    • Discrimination of adrenocortical carcinoma from other adrenal lesions: use of a new 13 steroid serum panel based on LC-MS/MS

      ea0038p398
    • Glucocorticoid-induced lipolysis across human ageing and the relationship to fat mass and androgens

      ea0038p399
    • Rapid equilibriation of cortisol between the free and total plasma pools

      ea0038p400
    • Do androgens lead to increased erythropoiesis in women with congenital adrenal hyperplasia?

      ea0038p401
    • Bioinformatic analysis of microRNAs associated with aldosterone secretion

      ea0038p402
    • Immunogenicity in AAD patients treated with depot tetracosactide

      ea0038p403
    • Unveiling the complexity of the undifferentiated zone in the human adrenal cortex

      ea0038p404
    • Cytosolic innate immune receptor RIG-I amplifies glucocorticoid action within lung epithelial cells

      ea0038p405
    • Quantitative analysis of an adrenal steroid profile, canrenone, and mifepristone in plasma by triple quadrupole mass spectrometry

      ea0038p406
    • Conventional vs modified release hydrocortisone in mitotane treated patients with adrenocortical cancer

      ea0038p407
    • Effects of diet and gender on postprandial salivary glucocorticoid levels and bile acid excretion in healthy volunteers

      ea0038p408
    • Shocking? A systematic review of adrenal insufficiency in adults on oral steroids

      ea0038p409
    • Hormone replacement therapy with prednisolone in adrenal insufficiency patients: data from the European Adrenal Insufficiency Registry (EuAIR)

      ea0038p410
    • The effect of adrenalectomy on cardiovascular morbidity in adrenal tumor patients with subclinical Cushing's syndrome: systematic review and meta-analysis

      ea0038p411
    • DHEA reduces the palmitate-induced apoptosis in L6 myotubes

      ea0038p412
    • Profiling of multiple vitamin D metabolites in a healthy human cohort by high-throughput liquid chromatography-tandem mass spectrometry analysis

      ea0038p413
    • Support from clinical audit data for liberal minimum 0900 h cortisol cut-off to avoid short Synacthen tests

      ea0038p414
    • Lineage conversion of human cells to an adrenocortical phenotype: a new technology to study the adrenal gland

      ea0038p415
    • Steroid-dependent patients with multiple co-morbidities are more vulnerable to adrenal crisis

      ea0038p416
    • Comorbidities are the norm for steroid-dependent patients and predispose to adrenal crisis

      ea0038p417
    • Lack of awareness contributes to delayed diagnosis and inappropriate management in men with low testosterone: findings from a UK study of men diagnosed with hypogonadism

      ea0038p418
    • Heterogeneity in the clinical management of adrenal insufficiency - data from EU-AIR

      ea0038p419
    • Phaeochromocytoma related reversible Takotsubo cardiomyopathy

      ea0038p420
    • Iatrogenic Cushing's syndrome secondary to combined oral contraceptive pill in a patient with congenital adrenal hyperplasia

      ea0038p421
    • Bilateral adrenal haemorrhage in a patient with anti-phospholipid syndrome

      ea0038p422
    • Transient adrenal insufficiency following acute bilateral adrenal haemorrhage

      ea0038p423
    • X-linked adrenoleukodystrophy - how to improve identification in the Addison's population

      ea0038p424
    • Primary testicular lymphoma with bilateral adrenal masses and adrenal insufficiency

      ea0038p425
    • Adrenal insufficiency from bilateral adrenal haemorrhage in a postoperative patient on warfarin

      ea0038p426
    • Cushing's syndrome secondary to bilateral functioning adrenocortical adenoma

      ea0038p427
    • Complications of CAH in pregnancy

      ea0038p428
    • Liquorice induced hypermineralocorticoidism - a case report from Midyorkshire Hospitals NHS trust

      ea0038p429
    • Autoimmune polyendocrine syndrome type 4

      ea0038p430
    • A severe case of ectopic ACTH presenting with Cushing's syndrome with hypokalaemia, hypomagnesemia, hypophosphatemia, hyponatraemia and hypocalcaemia

      ea0038p431
  • Thyroid
  • • Peripheral blood microRNA markers in patients with papillary thyroid cancer

      ea0038p432
    • Effect of hypothyroidism on pancreatic [beta]-cell mass and circulating insulin concentration in the ovine foetus

      ea0038p433
    • Thyroid hormones and mitochondrial development in skeletal muscle of foetal sheep near term

      ea0038p434
    • The natural history of subclinical hyperthyroidism due to Graves' disease

      ea0038p435
    • Epitopes, specificity, functional effects, and IgG subclasses of anti-calcium-sensing receptor autoantibodies in patients with autoimmune polyendocrine syndrome type 1

      ea0038p436
    • Reliability of thyroid ultrasounds in assessment of thyroid nodules

      ea0038p437
    • Subclinical and overt hypothyroidism in pregnancy: what happens next?

      ea0038p438
    • Soy protein with isoflavones impairs thyroid function

      ea0038p439
    • Increased rehospitalisation rate and cardiovascular morbidity in inpatients with hyperthyroidism - a matched case-control study

      ea0038p440
    • Small fibre dysfunction in hypothyroidism - a prospective study using methods of small fibre function and structure

      ea0038p441
    • A cross-sectional survey to determine iodine status of school girls living in Northern Ireland

      ea0038p442
    • Thyroid abnormalities during anti-PD1 cancer immunotherapy

      ea0038p443
    • The effect of isoflavone-free soy protein supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: a randomised double blind crossover study

      ea0038p444
    • A cross sectional survey of dietary iodine intake in pregnant women living in Northern Ireland

      ea0038p445
    • Is one benign thyroid FNA cytology sufficient to out rule malignancy? A university teaching hospital experience

      ea0038p446
    • The value of second fine needle aspiration cytology tests when investigating benign thyroid nodules (Thy2/Thy2c)

      ea0038p447
    • Management of amiodarone induced thyrotoxicosis within the United Kingdom: is it time for a consensus guideline? A single centre retrospective review

      ea0038p448
    • Serum thyroid stimulating hormone concentration after withdrawal of thionamides as a predictor of Graves' disease outcome

      ea0038p449
    • Maternal thyroid function in pregnancy and risk of breech presentation

      ea0038p450
    • Ultrasound guided thyroid FNA with cytopathology in-attendance significantly improved accuracy in a university teaching hospital

      ea0038p451
    • Diagnostic and therapeutic challenges in medullary thyroid carcinoma

      ea0038p452
    • Less is more: superior efficacy and tolerability of 400 MBq radioactive iodine for management of thyrotoxicosis

      ea0038p453
    • Incidental thyroid malignancy in Grave's thyrotoxicosis

      ea0038p454
    • Management of thyroid cancer: a 5-year retrospective audit

      ea0038p455
    • Thyroid eye disease audit - the Wolverhampton experience

      ea0038p456
    • R438H missense mutation related generalised resistance to thyroid hormone (GRTH): a case series report in three generations

      ea0038p457
    • Imaging in subclinical hyperthyroidism: findings from a single centre cohort

      ea0038p458
    • Qualitative analysis of ultrasound reports assessing radiological descriptors of thyroid nodules - a retrospective pilot audit

      ea0038p459
    • An audit of hyperthyroidism in pregnancy

      ea0038p460
    • Thyroxine administration: a challenging case

      ea0038p461
    • Thyroid deficiency refractory to treatment: is this a case for DOT?

      ea0038p462
    • Recurring thyroid eye disease: a diagnostic dilemma

      ea0038p463
    • Timing of food intake and L-thyroxine replacement - a cost saving simple change of phrasing in the British National Formula

      ea0038p464
    • The value of thyroxine absorption test followed by weekly thyroxine administration in determining the cause of persistent hypothyroidism despite high dose L-thyroxine treatment: a case report

      ea0038p465
    • Resistance to thyroid hormone in a family of Bangladeshi extraction

      ea0038p466
    • More than meets the eye: a case of longstanding hypothyroidism due to Hashimoto's thyroiditis presenting with unilateral thyroid eye disease

      ea0038p467
    • TSH receptor antibodies testing in hypothyroid pregnant women

      ea0038p468
    • Thyroid dysfunction secondary to antiviral therapy: a simple management protocol

      ea0038p469
    • Case report: propylthiouracil-induced ANCA-associated-vasculitis

      ea0038p470
    • Odd TFTs: when it does not fit, it probably is not right!

      ea0038p471
    • Primary radioactive iodine ablation for TSH secreting adenoma - an uncommon treatment for a rare disease

      ea0038p472
    • An unusual cause of hypercalcaemia

      ea0038p473
    • Buying time: a unique case of delayed thyroidectomy post thyroid storm

      ea0038p474
    • A disputable but effective therapy in neutropenia associated with Graves' disease

      ea0038p475
    • Late stage Hashimoto's or Riedel's? A case report illustrating this diagnostic conundrum

      ea0038p476
    • Investigating pyrexia whilst awaiting thyroidectomy for Thy 3, Hurthle cell neoplasia

      ea0038p477
    • The roller-coaster ride of thyroid function before, during and after pregnancy

      ea0038p478
    • Metastatic differentiated thyroid cancer with undetectable serum thyroglobulin: diagnostic, management and follow-up challenges

      ea0038p479
    • Thionamide resistant Graves' disease - it's not always poor compliance

      ea0038p480
    • Recurrent Hashimoto's encephalopathy: a case report of reversible coma and status epilepticus

      ea0038p481
    • Hyperthyroidism in an elderly patient intolerant to carbimazole

      ea0038p482
    • Radioiodine therapy in benign thyroid disease

      ea0038p483
    • Severe myxoedema complicated by peri-orbital oedema, gum oedema, SIADH and ECG changes

      ea0038p484
    • Inadequate TSH - resistance to thyroid hormones: two case reports

      ea0038p485
    • Management of hypothyroidism in pregnancy with armour thyroid

      ea0038p486
    • A case of thyroid hormone resistance with unusually elevated free thyroxine

      ea0038p487
    • Hypercalcaemia: look beyond the usual

      ea0038p488
    • If it feels like myxoedema coma, then it probably is!

      ea0038p489
    • Preoperative parathyroid imaging: a retrospective audit

      ea0038p490