ECE2015 Guided Posters Thyroid – hypothyroidism (10 abstracts)
Cardiovascular risk factors in autoimmune thyroiditis and subclinical hypothyroidism
Celestino Neves 1 , César Esteves 1 , João Sérgio Neves 1 , Oksana Sokhatska 2 , Miguel Pereira 1 , Carmo Palmares 2 , Camila Dias 3 , Davide Carvalho 1 , Luís Delgado 2 & José Luís Medina 1
1Endocrinology Service, Faculty of Medicine, São João Hospital, University of Porto, Porto, Portugal; 2Immunology Department, Faculty of Medicine, São João Hospital, University of Porto, Porto, Portugal; 3Department of Biostatistics and Medical Informatics, Faculty of Medicine, São João Hospital, University of Porto, Porto, Portugal.
Introduction: Subclinical hypothyroidism appears to be related with an increased risk of cardiovascular disease. It was our objective to evaluate the relationship between autoimmune thyroiditis, subclinical hypothyroidism, and cardiovascular risk factors.
Methods: We evaluated thyroid function tests, autoimmunity, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, ApoA1, ApoB, Lp(a), homocysteine, high sensibility CPR, folic acid, vitamin B12, HOMA-IR, HOMA-β, QUICKI, HISI, WBISI, and IGI in 186 subjects with autoimmune thyroiditis and in euthyroid state and in 69 subjects with autoimmune thyroiditis and subclinical hypothyroidism. Statistical analysis was performed with Mann–Whitney U test, logistic regression, and Spearman correlations. In our study group, 94% of patients were females. The median age was higher in the euthyroid group (49 years vs 42 years; P=0.03). The results were adjusted for age and BMI and are expressed by median±percentiles 25 and 75. Statistical significance was considered for a bilateral value of P<0.05.
Results: Patients with higher levels of total cholesterol (OR=1.008; P=0.03), CPR (OR=1.684; P=0.04), or anti-thyroglobulin antibodies (OR=1.002; P=0.02) have an increased likelihood of having subclinical hypothyroidism. In the total group of patients, we observed positive correlations between TSH and CPR (r=0.132; P=0.043), between TSH and HOMA-IR (r=0.158; P=0.029), between free T3 and HDL-cholesterol (r=0.16; P<0.01), and between free T4 and IGI (r=0.22; P<0.01). TSH levels correlated negatively with QUICKI (r=−0.16; P=0.02), HISI (r=−0.16; P=0.03) and WBISI (r=−0.16; P=0.02) and free T4 levels with WBISI (r=−0.18; P=0.01). In the group with subclinical hypothyroidism, we found negative correlations between free T3 and homocysteine (r=−0.36; P=0.01) and between free T4 levels and anti-TPO antibodies (r=−0.28; P=0.02).
Conclusion: The interrelations between thyroid function, lipid profile, CPR, and insulin resistance demonstrate an increase of cardiovascular risk in subclinical hypothyroidism due to autoimmune thyroiditis.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more