ECE2015 Guided Posters Diabetes and obesity – Translational diabetes (7 abstracts)
Can physical activity modify the impact of the genes on the incidence of type 2 diabetes mellitus?
Lukasz Szczerbinski 1 , Witold Bauer 2 , Joanna Goscik 3 , Natalia Wawrusiewicz-Kurylonek 1 , Magdalena Paczkowska 2 , Magdalena Niemira 2 , Anna Citko 2 , Michal Ciborowski 2 , Katarzyna Maliszewska 1 , Edyta Adamska 2 , Adam Kretowski 1, & Maria Gorska 1
1Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland; 2Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland; 3Centre for Experimental Medicine, Medical University of Bialystok, Bialystok, Poland.
The exact mechanism of the development of T2DM is still unclear, however, it is known that important role is played by both environmental and genetic factors. In this study we focused on describing the interactions between environmental and genetic factors and answering the question whether physical activity can modify the impact of the genes on the incidence of T2DM. We recruited 921 subjects (median age: 38 years; 49.7% man; mean BMI: 28.1) from the cohort 1000 Polish Longitudinal University Study (PLUS). PA has been assessed using International Physical Activity Questionnaire, and 37 single nucleotide polymorphisms (SNPs) associated with T2DM in GWAS have been genotyped, to explore interaction between the SNPs and the level of PA on the incidence of T2DM. Genetic risk score (GRS) as a weighted sum of risk alleles have been calculated. We also calculated the percentage of T2DM cases within each of the four strata given by high and low GRS and PA using R software. To explore GRS and PA interactions, we examined associations of PA with T2DM in each group. The incidence of T2DM was lower among physically active individuals in high GRS group (8.6% in high PA class vs. 13.8% in low PA class, P <0.03) as well as in low GRS group (4.4% in high PA class vs 8.7% in low PA class, P <0.03). We also found that individuals with TT variant in rs10885122 (ADRA2A) has slightly lower values of average PA compared to those with TG and GG genotypes (P<0.006). In our study we proved that the genetic predisposition to T2DM can be reduced by increasing the PA, even among patients at high genetic risk. This allows to conclude that, through the use of physical activity we can reduce the incidence of T2DM, even in patients with a genetic predisposition.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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