The role of antithyroglobulin, antiperoxidase and anti-TSH autoantibodies in amiodarone induced thyrotoxicosis or amiodarone induced hypothyroidism (a two-center study)

Agata Czarnywojtek; Malgorzata Zgorzalewicz-Stachowiak; Marta Fichna; Kosma Wolinski; Maria Teresa Plazinska; Adam Stangierski; Pawel Gut; Izabela Miechowicz; Hanna Komarowska; Rafal Czepczynski; Leszek Krolicki; Marek Ruchala

doi:10.1530/endoabs.37.EP956

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Endocrine Abstracts (2015) 37 EP956 | DOI: 10.1530/endoabs.37.EP956

ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)

The role of antithyroglobulin, antiperoxidase and anti-TSH autoantibodies in amiodarone induced thyrotoxicosis or amiodarone induced hypothyroidism (a two-center study)

Agata Czarnywojtek ^1, , Malgorzata Zgorzalewicz-Stachowiak ³ , Marta Fichna ¹ , Kosma Wolinski ¹ , Maria Teresa Plazinska ⁴ , Adam Stangierski ¹ , Pawel Gut ¹ , Izabela Miechowicz ⁵ , Hanna Komarowska ¹ , Rafal Czepczynski ¹ , Leszek Krolicki ⁴ & Marek Ruchala ¹

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¹Department of Endocrinology, Metaboilsm and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland; ²Department of Pharmacology, Poznan University of Medical Sciences, Poznan, Poland; ³Department of Health Prophylaxis, Laboratory of Medical Electrodiagnostics, Poznan University of Medical Sciences, Poznan, Poland; ⁴Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Computer Science and Statistic, Poznan University of Medical Sciences, Poznan, Poland.

Purpose: In the recent study it has been reported, that elevated serum concentrations of TSH receptor (TSH-R), antithyroglobulin (Tg), antiperoxidase (TPO) autoantbodies (Abs) may be observed in the subjects treated for amiodarone induced thyrotixicosis (AIT) type I, decreased in type II of AIT, or changed in amiodarone induced hypothyroidism (AIH). This study was done to analyse the changes of Tg-Abs, TPO-Abs and TSH-R-Abs titer in euthyroid, hyperthyroid (AIT), and hypothyroid (AIH) patients.

Methods: The study consisted of 217 patients diagnosed in the Chair and Department of Endocrinology, Metabolism and Internal Medicine, Poznan, and 63 patients treated in the Department of Nuclear Medicine, in Warsaw, Poland between January 2003 and December 2014. Titer of serum TPO-Abs, Tg-Abs, TSH-R-Abs were analyzed retrospectively, in euthyroid patients with the history of hyperthyroidism prior to re-administration of amiodarone (group A), patients with AIT who discontinued AM therapy (group B), patients with AIT chronically treated with AM (group C), and hypothyroid patients (AIH, group D).

Results: Statistically significant differences were observed in serum Tg-Abs values between groups: A and B (P=0.001), A and D (P=0.001), B and D (P=0.01), A and C (P=0.001), B and C (P=0.001). In case of serum level of TPO-Abs, we found statistically significant differences between groups: A and C (P=0.05), B and C (P=0.001), C and D (P<0.05). Serum TSH-R-Abs were not elevated in any of the studied groups, and the titers did not differ between patients with AIT and AIH. TPO-Abs and Tg-Abs were in normal ranges in all groups.

Conclusion: Normal or slightly decreased titer of TPO-Abs, Tg-Abs, TSH-R-Abs were observed in all studied groups. Observed statistically significant differences were not clinically relevant. Discontinuing or continuing amiodarone therapy had no influence on the titer of autoantibodies.