Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2015) 37 EP943 | DOI: 10.1530/endoabs.37.EP943

ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)

Dynamic thiol/disulfide homeostasis in patients with autoimmune subclinical hypothyroidism

Ihsan Ates 1 , Mustafa Altay 1 , Fatma Meric Yilmaz 2, , Canan Topcuoglu 2 , Salim Neselioglu 3 , Özcan Erel 3 & Nisbet Yilmaz 1


1Department of Internal Medicine, Ankara Numune Education and Research Hospital, Ankara, Turkey; 2Department of Biochemistry, Ankara Numune Education and Research Hospital, Ankara, Turkey; 3Department of Biochemistry, Medical Faculty, Yildirim Beyazit University, Ankara, Turkey.


Objective: To investigate dynamic thiol/disulphide homeostasis in autoimmune subclinical hypothyroidism.

Materials and methods: 48 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto’s thyroiditis and not yet on any treatment and 48 healthy subjects without any known disease were enrolled. Thiol/disulfide homeostasis (native thiol(-SH)–disulphide(-S-S-) exchanges) was measured in both groups with new method developed by Erel and Neselioglu. The half of the difference between total thiol (-SH+-S-S-) and -SH concentrations gave the -S-S- bond amount.

Results: In patients with subclinical hypothyroidism, -SH level and -SH/(-SH+-S-S-) ratio was found to be lower than that of the control group. -S-S- level (P=0.004), -S-S-/-SH (P=0.001), and -S-S-/(-SH+-S-S-) (P=0.001) ratio was higher in patients with subclinical hypothyroidism as compared to that of the control group. A positive correlation was found between anti-TPO and anti-Tg levels and -S-S-/-SH ve -S-S-/(-SH+-S-S-) levels while a negative correlation was found with -SH/(-SH+-S-S-) level.

Conclusions: Thiol/disulfide homeostasis was found to have a tendency towards -S-S- formation in patients with subclinical hypothyroidism and thyroid autoantibodies were correlated positively with thiol oxidation. Abnormal thiol/disulfide homeostasis in patients with Hashimoto’s thyroiditis, is whether a cause or a consequence, may be illustrated by using thiol-containing drugs and following autoantibody levels. The efficacy, dose and duration of thiol drugs may be monitored easily, effectively, quickly and cheaply by the method developed by Erel and Neselioglu.

Article tools

My recent searches

No recent searches.