ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)
The evaluation of TSH-receptor antibody in hyperthyroid patients treated with surgery or radioactive iodine
Ahmet Dirikoc 1 , Fatma Neslihan Cuhaci 1 , Husniye Baser 2 , Cevdet Aydin 1 , Oya Topaloglu 1 , Mehmet Kilic 3 , Seyda Turkolmez 4 , Reyhan Ersoy 1 & Bekir Cakir 1
1Department of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey; 2Department of Endocrinology and Metabolism, Ataturk Education and Research Hospital, Ankara, Turkey; 3Department of General Surgery, Ataturk Education and Research Hospital, Ankara, Turkey; 4Department of Nuclear Medicine, Ataturk Education and Research Hospital, Ankara, Turkey.
Introduction: Radioactive iodine (RAI) therapy is widely used in the treatment of hyperthyroidism especially in patients with Graves’ disease (GD), toxic multinodular goitre (TMNG), and toxic adenoma. RAI may lead to worsening of the autoimmunity with the elevation of TSH-receptor antibody (TRAB). In this study, we aimed to compare the effects of surgery or RAI treatment on TRAB.
Methods: Hyperthyroid patients were divided into three groups; patients in group 1 (n=23) had GD conducted to RAI, in group 2 (n=18) had TMNG referred to RAI, and group 3 (n=12) had GD who underwent to surgery. Before and 12 months after RAI and surgery, sera were collected and analysed for the presence of TRAB.
Results: In group 1, there were eight patients (34.8%) before treatment and 14 patients after treatment with TRAB positivity (P=0.311). In group 2, before treatment there were two patients (11.1%) with TRAB positivity, whereas after treatment there were four patients (22.2%) (P=0.423). In group 3, TRAB positivity were in six patients (50%) and in one patient (8.3%) before and after treatment respectively (P=0.296). However, there was no difference in TRAB positivity between groups 1 and 3 before treatment (P=0.383), TRAB positivity was statistically higher in group 1 than group 3 at 12 months of treatment (P=0.003). There was no difference between groups 1 and 2 before treatment (P=0.080). TRAB positivity was significantly higher in group 1 than group 2 at 12 months of the treatment (P=0.013).
Conclusion: RAI treatment can induce autoimmunity in patients with TMNG similar as in patients with GD. We observed similar ratios of TRAB positivity in patients with GD and TMNG before and 12 months after treatment. Whereas 12 months after the treatment, we demonstrated higher TRAB titres in GD patients treated with RAI than underwent to surgery.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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