Isolated cutaneous findings of systemic lupus erythematosus due to propylthiouracil

Gamze Erfan; Kaan Tasolar; Meltem Oznur; Murat Yilmaz

doi:10.1530/endoabs.37.EP938

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Endocrine Abstracts (2015) 37 EP938 | DOI: 10.1530/endoabs.37.EP938

ECE2015 Eposter Presentations Thyroid (non-cancer) (160 abstracts)

Isolated cutaneous findings of systemic lupus erythematosus due to propylthiouracil

Gamze Erfan ¹ , Kaan Tasolar ¹ , Meltem Öznur ² & Murat Yılmaz ³

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¹Dermatology, Tekirdag, Turkey; ²Pathology, Tekirdag, Turkey; ³Endocrinology and Metabolism, Tekirdag, Turkey.

Propylthiouracil (PTU), used to treat thyroid dysfunctions such as Graves’ disease, rarely induces lupus-like syndrome. A 52-year-old woman developed dermatological findings of systemic lupus erythematosus with malar rash, photosensitivity and discoid lupus erythematosus-like lesions, after 3 weeks of exposure to the drug. ANA and anti-dsDNA were positive. Skin biopsy of face revealed vacuolar changes in basal layer and lymphoid infiltration in perivascular region of dermis. No other organ involvement was diagnosed. PTU treatment was stopped and with oral prednisolone 40 mg daily, in 3 weeks she had resolution of lesions. The patient has no skin lesions in 2-month follow-up. This is a report of isolated skin findings of lupus-like syndrome with positive serologies and without any other organ involvement. The physicians should be aware of this rare but potentially serious, possible adverse effect of PTU.