Endocrine Abstracts

Introduction: Vitamin D is important for proper functioning of all body tissues. Receptors for vitamin D are also presence in thyroid gland. It’s open questions how this vitamin could modulate the thyroid function.

Aim: The aim of the study was assess the concentrations of vitamin D as well as antiTPO level among patients with thyroid dysfunction hospitalised on Endocrinology Department.

Materials and methods: The study was conducted among 86 patients, which were divided into three groups: Autoimmune Thyroid Disorders AITD (including Hashimoto disease, Graves Basedow disease) (n=40), non autoimmunological diseases of thyroid gland (e.g. thyroid goitre) (n=16), and persons without thyroid dysfunction (n=30) as control group. The Kruscal Wallis test and Spearman rank correlation were used. The collected data were statistically analysed, α=0.05.

Results: The mean age in group with autoimmune thyroid diseases AITD was 46.5±15.9, mean of antiTPO was 316.79±303.94 IU/ml, vitamin D 18,53±9,17 ng/ml. The mean of age in group with non autoimmunological diseases was 43.75±17.81, antiTPO 0.63±1 IU/ml, vitamin D 18.3±7.42 ng/ml and among patients without thyroid diseases the mean age was 28.17±9.78 and antiTPO 0.57±0.98 IU/ml, vitamin D 16.54±5.51 ng/ml. The statistical significance difference was observed between groups according to age (P=0.0000) and antiTPO level (P=0.0000), the statistical difference wasn’t observed between vitamin D concentration in analysed groups. In all group of 86 patients positive correlation between age and antiTPO level was observed (P=0.00003). Obesity was most frequently observed among patients with AITD. The vitamin D deficiency defined as level below 20 ng/ml was observed among 71% all of hospitalized patients.

Conclusions: Screening of thyroid function should be done among patients with overweight, obesity and also among patients over 40. Vitamin D deficiencies should be diagnosed and corrected according to guidelines recommended in Central Europe.