ECE2015 Eposter Presentations Thyroid cancer (90 abstracts)
Thyroid cytology–biopsy correlation
Inmaculada Gavilán-Villarejo 1 , Laura Larrán-Escandón 1 , Isabel Mateo-Gavira 1 , Pilar Roldán-Caballero 1 , Cristina López-Tinoco 1 , Diego Martínez-Parra 2 , Eduardo Vallejo-Roca 3 & Manuel Aguilar-Diosdado 1
1Endocrinology, Puerta del Mar Hospital, Cádiz, Spain; 2Pathological Anatomy, Puerta del Mar Hospital, Cádiz, Spain; 3Radiology, Puerta del Mar Hospital, Cádiz, Spain.
Background: Fine-needle aspiration (FNA) biopsies are the cornerstone of preoperative evaluation of thyroid nodules, but FNA diagnostic performance has varied across different studies. We conducted a study to evaluate the effectiveness of ultrasound guided FNA in the thyroid nodule and to review the correlation between cytopathology and histopathology.
Methods: Prospective FNAs were collected from 332 patients who underwent thyroid surgery between 2008 and 2013. The cytological sample was assessed by a single consultant pathologist and was classified as inadequate, non-neoplastic, neoplastic, or indeterminate. The histology were classified as non-neoplastic (benign), neoplastic (malignant). Sensitivity, specificity, positive predictive value, and negative predictive value were calculated.
Results: The mean age was 51.65±13.40 years, 279 (84%) were women. The average size of nodules was 3.35±1.41 cm. Multinodular goiter presented with dominant nodule 239 (72%) patients and 93 (28%) single nodule. Cytology analysis showed 216 (66.3%) benign, 86 (26.4%) indeterminate, and 24 (7.4%) malignant. One hundred and ninety-seven (59.3%) patients underwent total thyroidectomy. From this population indeterminate cytology rate were 75 (87.2%) benign and 11 (12.6%) malignant histopathology. The FNAs had a sensitivity of 84.62%, specificity of 99.07%, positive predictive value of 91.67%, and negative predictive value 98.15%.
Conclusions: Ultrasound-guided FNA provides important information for the diagnosis and the preoperative evaluation of thyroid nodules. The low rate of false-positive and false-negative results suggests that it might be enough for surgical planning for thyroid nodule.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more